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. 2022 Jun 17;8:20. doi: 10.1038/s41540-022-00230-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Volcano plot indicating the fold change (y axis) and significance (x axis) of the genes differentially expressed between S and R clones. b First two principal components derived from the expression profiles of each clone. c Most significantly up or down-regulated gene sets (Hallmark and Reactome from MSigDB) in individual R clones compared to all S clones. Significant gene sets (q < 0.005) enriched (score > 1.5) or depleted (score < −2) in at least one clone are reported. Color gradient indicates enrichment score. d Treatment with 5 µM ruxolitinib (Rux) significantly decreases the growth-rate corrected half maximal inhibitory concentration (GR50) in both Parental and R clones. The results of 3 dose-response experiments, 3 replicates per experiment are presented. Significance was measured using Wilcoxon Test (* < 0.05, ** < 0.01, *** < 0.001). Boxes represent the top and bottom quartiles of the distribution and whiskers are extended to 1.5 time the interquartile range.