Figure 6 -. Characterization of the ‘Pink’ differentially co-expressed module:

a) Spearman correlation of submodule eigengenes in high risk (HR), low risk (LR), and normal glomerular tissue (HR – red; LR – black, normal – blue). Eigengenes summarize overall gene expression behavior in each submodule and were defined as the first principal component of the group- specific gene expression matrices. Submodules are labeled along the x and y-axis. Diagonal – eigengene density plots. Below diagonal – scatter plot comparing submodule eigengenes (each point represents a sample). Above diagonal – Spearman correlations stratified by group (“Corr” – all groups combined). Correlation significance - “***” p < 0.01, “**” p<0.01, “*” p<0.05, “.” p<0.1. b) HR and LR correlation schematic of the four ‘Pink’ submodules with selected enriched biology. c) We identified the top 10% of Pink module genes differentially co-expression with NKIRAS1, resulting in 30 and 55 genes from F and G submodules, respectively. Presented here are HR, LR, and healthy NKIRAS1 correlations with other genes from the corresponding enrichment analysis. These genes are among the strongest differentially correlated genes with NKIRAS also enriched for known biology. Absolute correlations are stronger in the LR group compared to the HR group and correlation patterns in the healthy tissue are more similar to LR, compared to HR group.