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. 2022 Jun 18;307(6):1811–1822. doi: 10.1007/s00404-022-06614-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Case 2: Placenta from intrauterine demise 15 + 2 weeks of gestation. a Extensive perivillous fibrin deposits involving the placental tissue from the chorionic plate (CP) until basal plate (BP). b Very focal area of preserved chorionic villi with open intervillous space (*) within the placental tissue. c Focal areas of histiocytic intervillositis (*) within intervillous fribrin deposits. d Fresh necroses of the villous trophoblast with a pale red appearing of the villous trophoblast, some trophoblastic nuclei are still preserved (please compare to Fig. 1e, f). e Extensive and strong staining of the villous trophoblastic cells for SARS-CoV-2, some villous stromal cells with weak staining (arrows). f, g SARS-CoV-2-specific RT-PCR amplification plots with positive FAM-/ROX fluorescence signals within the placental tissue. Compared to Figs. 3c and d, there is a higher viral load in case 2, indicated by early and strong increase of the plotting curves which is stronger than the positive control curve