Table 1.
Regulation of PGT-initiated pathways
| Regulatory Protein/Receiver Domain | PGT | Organism | Target protein | Regulated step | Effect of Regulation | Pathway |
|---|---|---|---|---|---|---|
| Polytopic Pathways | ||||||
| PknB (PASTA-eSTKs) | MraY | Mycobacterium tuberculosis | GlmU | UDP-GlcNAc synthesis | reduced activity | PG |
| MviN | glycan translocation | inhibited by FhaA | PG | |||
| PonA1 | transglycosylation/transpeptidation | activation | PG | |||
| CwlM | lipid II export via MurJ | cellular localization, activation of MurA | PG | |||
| PrkA (PASTA-eSTKs) | MraY | Listeria monocytgenes | YvcK | cell-wall homeostasis | unknown | unknown |
| GpsB | transglycosylation/transpeptidation | ClpCP-dependent degradation of MurA | PG | |||
| Wnt/β-catenin | DPAGT1 | Homo sapiens | --- | gene expression | increased N-glycosylation of E-cadherin | N-glycosylation |
| Monotopic Pathways | ||||||
| RcsB/RcsC | WcaJ | Escherichia coli | RcsA | gene expression | RcsA regulates gene expression | colanic acid |
| CapB/CapA | CapM | Staphylococcus aureus | CapO | UDP-ManNAc synthesis | activation | CPS |
| CapM | phosphoglycosyl transfer | increases activity | CPS | |||
| CapE | UDP-FucNAc synthesis | increases activity | CPS | |||
| Wzc | WcaJ | Escherichia coli | Ugd | UDP-glucuronic acid synthesis | increases activity | colanic acid |
| CpsD/CpsC | CpsE | Streptococcus pneumoniae | unknown | unknown | regulates CPS length | CPS |
| EpsD/EpsC | EpsE | Streptococcus thermophilus | EpsE | phosphoglycosyl transfer | activation | EPS |