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. 2022 Jun 17;22:669. doi: 10.1186/s12885-022-09725-8

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — The activity of MIF inhibitors on neuroblastoma cell lines and BM primary cultures. Cytotoxic activity of A) AMD3100 (50-0.0001 μM), B) ISO-1 (50-0.2 μM) and C) 4-IPP (50-0.2 μM) in a panel NB cell lines and BM primary culture under regular conditions (n = 6). Flow cytometry quantification in bar graphs of 4-IPP activity on D) BM, E) LAN-1, and F) co-cultures LAN1:BM ratio (1:10) treated with vehicle or 4-IPP 30 μM after 72 h at regular conditions (n = 2)