Table 1.

Features different types of miRNA, their expression pattern, signaling pathways, functions, and target regulators

miRNA	Expression Pattern and No of Clinical Samples	Signaling pathways	Target Regulators	Function	References
miRNA-1	Downregulated 5 non-neoplastic ovarian tissues and 13 ovarian cancer specimens	Akt, ERK1/2	c-met	miRNA-1 takes part in tumor suppression by inhibiting the expression of c-met	[24]
miRNA-124	Downregulated 13 pairings of adjacent non-tumor tissues and ovarian cancer tissues	–	SphK1	Downregulation of SphK1 is supported by miR-124 which suppresses migration and invasion of Ovarian Cancer	[25]
miRNA-335	Downregulated ovarian cancer tissues and non-tumor tissues in ten pairs	–	Bcl-W	In epithelial ovarian cancer, miR-335 is responsible for poor survival	[26]
miRNA-215	Downregulate A total of 48 pairs of ovarian cancer tissues and non-tumor tissues were studied.	MAPK	NOB1	NOB1is helpful in inhibiting the growth of tumor cells with the help of miR-215	[27]
miRNA-429	Downregulated A total of 72 pairs of ovarian cancer tissues and non-tumor tissue were used in this study.	–	ZEB1	Cisplatin sensitivity increases due to Overexpression of miR-429 which help in reducing autophagy-related protein anti-LC3A/Band Anti-ATG7	[28]
miRNA-200c	Upregulated	–	ZEB1	Inhibition of EMT in CD44 + CD117 + CSCs is supported by miR-200c overexpression which decreases ZEB1 expression.	[29]
miRNA-7	Upregulated 180 samples of ovarian cancer, 66 samples of normal ovarian tissue	AKT, ERK1	–	The overexpression of miR-7 in SKOV3 cells increases cell invasion and migration.	[22]
miRNA-25 miRNA-93	Downregulated 180 samples of ovarian cancer, 66 samples of normal ovarian tissue	AKT/ERK1	–	In SKOV3 cells, overexpression of miR-7 increases cell migration and invasion.	[22]
miRNA-137	Downregulated There were 21 cases of serous adenocystic carcinoma, 14 cases of mucinous adenocystic carcinoma, and 29 cases of normal ovarian tissues.	–	XIAP	miR-137 promotes Epithelial Ovarian cells to undergo cisplatin-induced apoptosis.	[30]
miRNA-490-3p	Downregulated 139 samples of ovarian cancer, 17 samples of normal ovarian tissue		CDK1	Induced expression of p53 Cell cycle phases G1/SorG2/arrest and apoptosis is promoted by overexpression of MiR-490-3P and reduces cell invasion, migration, proliferation, and invasion.	[31]
miRNA-145	Downregulated 38 samples of ovarian cancer, 9 samples of normal ovarian tissue	–	TRIM2	miR-145 mediates inhibition of TRIM2 which leads to the up-regulation.	[32]
miRNA-92	- 3 pairs of ovarian cancer tissues and non-cancer tissues adjacent	Wnt/β-catenin, STAT3	DKK1	In epithelial ovarian cancer, the STAT3-miR-92a-DKK1 pathway has potential therapeutic applications for targeted therapy	[33]
let-7d-5p	Downregulated 76 pairings of non-tumor tissues and ovarian cancer tissues	p53	HMGA1	The proliferation in ovarian cancer cells is suppressed and chemosensitivity is restored through the let-7d-5p by activating the p53 signaling pathway and silencing HMGA1.	[34]
miRNA-206	Downregulated 50 samples of ovarian cancer tissues	AKT/mTOR	c-Met	mir-206 could suppressor through c-Met/AKT/ mTOR signaling pathway	[35]
miRNA-630	Upregulated	–	APAF-1	miR-630 targets APAF-1 in re-sensitizing the cells to chemotherapy.	[36]
miRNA-152	Downregulated 8 pairs of cancer tissues and adjacent non-cancerous tissues	–	FOXP1	The proliferation and migration in epithelial ovarian cancer cells are inhibited by miR-152 by targeting FOXP1.	[37]
miRNA-142-3p	Downregulated There are 58 pairs of malignant and non-cancerous tissues in this study.	–	Sirtuin 1	The proliferation and chemoresistance in ovarian cancer could be inhibited by miR-142-3p by targeting SIRT1.	[38]
miRNA-221	Upregulated There are 63 pairs of cancer tissues and surrounding non-tumor tissues in this study.	–	APAF-1	The proliferation of cells in OC is promoted by overexpression of miRNA-221 by targeting APAF 1.	[39]
miRNA-145-5p	Downregulated -	Hippo	CTGF	Lower expression of miR-145-5p in Ovarian cancer is reviewed as a biomarker for diagnosis.	[40]
miRNA—199b-5p	Downregulated 79 EOC patient	Notch1	JAG1	Acquired chemoresistance in ovarian cancer is associated with miR-199b-5p via activating JAG1/ Notch1 signaling.	[41]
miRNA-141	Upregulated 132 fresh-frozen ovarian cancer samples	NF-kB	p38a MAPK, YAP1, KEAP1	In ovarian cancer cell lines, miR-141 overexpression can increase resistance to cisplatin. It also modulates cisplatin sensitivity by targeting KEAP1.	[42]
miRNA-424-5p	Downregulated surgical resection of 83 primary and 19 matched normal tissues	E2F1-pRB	CCNE1	G0/G1 cell cycle arrest and proliferation of ovarian cancer cells are being done miR-424-5p by targeting CCNE1 mediated E2F1- pRb signaling pathway.	[43]