Table 2.
Conventional echocardiographic and speckle-tracking derived measures of the study population
| Echocardiographic parameter | Total SSc population n = 20 |
Variance P value |
Cohort 1 SSc without PAH, n = 10 |
Variance P value |
Cohort 2 SSc with PAH n = 10 |
Variance P value |
|||
|---|---|---|---|---|---|---|---|---|---|
| A | B | A | B | A | B | ||||
| RA area, cm2 | 18.3 ± 4.7 | 18.4 ± 5.8 | 0.66 | 16.0 ± 2.3 | 15.5 ± 2.4 | 0.37 | 20.6 ± 5.5 | 21.3 ± 6.7 | 0.24 |
| RV hypertrophy yes, n (%) | 16 (80) | 16 (80) | 1 | 7 (70) | 7 (70) | 1 | 9 (90) | 9 (90) | 1 |
| RVH, cm | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.79 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.85 | 0.8 ± 0.1 | 0.8 ± 0.1 | 0.73 |
| RVIDD, cm | 3.0 ± 0.5 | 3.0 ± 0.5 | 0.68 | 2.7 ± 0.4 | 2.7 ± 0.4 | 1 | 3.2 ± 0.4 | 3.3 ± 0.4 | 0.66 |
| Mid RVOT, cm | 3.0 ± 0.5 | 3.0 ± 0.5 | 0.46 | 2.7 ± 0.4 | 2.8 ± 0.4 | 0.04 | 3.2 ± 0.4 | 3.2 ± 0.6 | 0.71 |
| Distal RVOT, cm | 2.0 ± 0.3 | 2.0 ± 0.4 | 0.55 | 2.0 ± 0.2 | 2.0 ± 0.2 | 0.78 | 2.1 ± 0.4 | 2.1 ± 0.4 | 0.61 |
| RV base, cm | 4.1 ± 0.6 | 4.1 ± 0.7 | 0.62 | 3.7 ± 0.5 | 3.6 ± 0.5 | 0.43 | 4.4 ± 0.6 | 4.6 ± 0.6 | 0.12 |
| RV mid, cm | 2.7 ± 0.7 | 2.7 ± 0.7 | 0.58 | 2.3 ± 0.4 | 2.3 ± 0.5 | 0.78 | 3.1 ± 0.7 | 3.1 ± 0.7 | 0.56 |
| RV length, cm | 8.4 ± 1.1 | 8.6 ± 1.1 | 0.06 | 7.7 ± 0.6 | 8.0 ± 0.5 | 0.10 | 9.1 ± 1.1 | 9.3 ± 1.2 | 0.36 |
| RVED area, cm2 | 21.6 ± 7.4 | 22.1 ± 7.9 | 0.37 | 17.2 ± 3.2 | 16.7 ± 2.8 | 0.61 | 26.0 ± 8.0 | 27.5 ± 7.7 | 0.25 |
| RVES area, cm2 | 10.7 ± 5.3 | 11.5 ± 6.0 | 0.10 | 7.9 ± 2.6 | 8.1 ± 2.2 | 0.82 | 13.5 ± 5.9 | 14.8 ± 6.8 | 0.07 |
| FAC, % | 52.1 ± 11.0 | 50.4 ± 12.5 | 0.27 | 54.2 ± 9.7 | 52.3 ± 6.9 | 0.35 | 50.0 ± 12.3 | 48.5 ± 16.6 | 0.55 |
| TAPSE, cm | 2.0 ± 0.4 | 2.0 ± 0.5 | 0.61 | 2.0 ± 0.3 | 2.0 ± 0.3 | 0.26 | 2.0 ± 0.5 | 2.1 ± 0.6 | 0.13 |
| S’ wave, cm/s | 12.4 ± 3.0 | 12.6 ± 2.9] | 0.54 | 14.0 ± 1.9 | 14.1 ± 1.6 | 0.63 | 10.7 ± 3.1 | 11.0 ± 3.2 | 0.72 |
| RVOT VTI, cm | 13.8 ± 3.5 | 13.6 ± 3.3 | 0.77 | 13.9 ± 2.7 | 14.8 ± 2.6 | 0.18 | 13.6 ± 4.3 | 12.4 ± 3.6 | 0.02 |
| RAP, mmHg | 5.5 ± 3.4 | 5.5 ± 3.4 | 1.00 | 4.0 ± 2.1 | 4.0 ± 2.1 | 1.00 | 3.6 ± 1.6 | 3.6 ± 1.6 | 1.00 |
| TR V max, m/s | 2.8 ± 0.8 (n = 19) | 3.0 ± 0.9 (n = 19) | 0.03 | 2.3 ± 0.4 | 2.4 ± 0.4 | 0.03 | 3.2 ± 0.7 (n = 9) | 3.5 ± 0.8 (n = 9) | 0.14 |
| RVSP, mmHg | 35.8 ± 18.4 (n = 19) | 42.2 ± 20.2 (n = 19) | 0.07 | 25.6 ± 9.3 | 28.7 ± 9.5 | 0.02 | 46.1 ± 19.2 (n = 9) |
55.7 ± 19.2 (n = 9) |
0.18 |
| TAPSE:PASP, mm/mmHg | 0.7 ± 0.4 | 0.6 ± 0.4 | 0.52 | 0.9 ± 0.4 | 0.8 ± 0.5 | 0.55 | 0.5 ± 0.2 | 0.8 ± 0.5 | 0.72 |
| Basal RVLSS, % | − 26.1 ± 8.0 | − 27.6 ± 9.0 | 0.20 | − 28.0 ± 5.8 | − 30.7 ± 7.2 | 0.11 | − 24.1 ± 9.7 | − 24.4 ± 9.8 | 0.86 |
| Mid RVLSS, % | − 19.8 ± 5.9 | − 21.0 ± 7.5 | 0.34 | − 23.8 ± 3.1 | − 26.2 ± 5.2 | 0.15 | − 15.8 ± 5.3 | − 15.7 ± 5.6 | 0.96 |
| Apical RVLSS, % | − 11.6 ± 6.0 | − 11.0 ± 5.4 | 0.64 | − 13.6 ± 7.0 | − 13.5 ± 6.6 | 0.95 | − 9.0 ± 3.9 | − 9.8 ± 4.6 | 0.46 |
| Global RVLSS, % | − 19.0 ± 5.1 | − 20.1 ± 5.7 | 0.13 | − 21.7 ± 2.8 | − 23.5 ± 3.8 | 0.11 | − 16.3 ± 5.5 | − 16.7 ± 5. 4 | 0. 64 |
Data are expressed as mean ± standard deviation for the continuous variables and as absolute number and percentage for the discrete variables, as appropriate
Abbreviations: IVS interventricular septum, PW posterior wall, LVIDD left ventricular internal dimension diastole, LVIDS left ventricular internal dimension systole, LA left atrial, RA right atrial, RV right ventricular, RVH RV hypertrophy, RVIDD right ventricular internal dimension diastole, RVOT right ventricular outflow tract, VTI velocity time integral, RVED right ventricular end-diastolic, RVES right ventricular end-systolic, FAC fractional area change, TAPSE tricuspid annular plane systolic excursion, S’ Tissue Doppler-derived right ventricular systolic excursion velocity, PAEDV pulmonary artery end-diastolic pressure, PAEDP pulmonary artery end-diastolic pressure, RAP right atrial pressure, TR tricuspid regurgitation, RVSP right ventricular systolic pressure, PVR pulmonary vascular resistance, WU Woods Unit, RVLSS right ventricular longitudinal systolic strain. RVSP and PASP are defined by the modified Bernoulli equation (4*(peak TR velocity)2 + RAP)