Table 4.

Intra- and inter-observer variability

Parameter	Panel A: Intra-observer variability			Panel B: Inter-observer variability
	Total SSc population	Cohort 1 (SSc without PAH)	Cohort 2 (SSc with PAH)	Total SSc population	Cohort 1 (SSc without PAH)	Cohort 2 (SSc with PAH)
	ICC (95% CI)	ICC (95% CI)	ICC (95% CI)	ICC (95% CI)	ICC (95% CI)	ICC (95% CI)
TAPSE, cm	0.949 (0.903–0.973)**	0.891 (0.730–0.956)	0.970 (0.926–0.988)**	0.904 (0.871–0.949)**	0.767 (0.409–0.908)**	0.940 (0.848–0.976) **
FAC, %	0.947 (0.900–0.972)**	0.930 (0.816–0.973)	0.952 (0.880–0.981)**	0.854 (0.563–0.938)**	0.719 (0.121–0.899)**	0.891 (0.660–0.960) **
S’ wave, cm/s	0.903 (0.816–0.948)**	0.975 (0.937–0.990)	0.823 (0.552–0.930)**	0.975 (0.954–0.987)**	0.912 (0.777–0.965)**	0.980 (0.950–0.992) **
RVOT VTI, cm	0.941 (0.889–0.969)**	0.891 (0.722–0.957)	0.963 (0.900–0.986)**	0.873 (0.760–0.933)**	0.655 (0.143–0.863)*	0.940 (0.850–0.976) **
Global RVLSS, %	0.925 (0.692–0.982)**	0.967 (0.917–0.987)	0.950 (0.775–0.990)**	0.978 (0.959–0.989)**	0.938 (0.843–0.976)**	0.980 (0.949–0.992) **
RVSP, mmHg	0.994 (0.989–0.997)**	0.950 (0.950–0.992)	0.993 (0.983–0.997)**	0.990 (0.981–0.995)**	0.965 (0.912–0.986)**	0.986 (0.966–0.995) **

Abbreviations: ICC intraclass coefficient correlation, CI confidence interval, TAPSE tricuspid annular plane systolic excursion, FAC fractional area change, S’ tissue Doppler-derived right ventricular systolic excursion velocity, RVOT right ventricular outflow tract, VTI velocity time integral, RVLSS right ventricular longitudinal systolic strain, RVSP right ventricular systolic pressure

^*P-value< 0.01

^**P-value< 0.001