Table 5.
Minimum detectable difference for each echocardiographic measure of right ventricular function
| Parameter | Minimal detectable difference | ||
|---|---|---|---|
| Total SSc population | Cohort 1 (SSc without PAH) | Cohort 2 (SSc with PAH) | |
| TAPSE, cm | 0.1 | 0.1 | 0.2 |
| FAC, % | 2.9 | 4.0 | 5.0 |
| S’ wave, cm/s | 1.3 | 0.8 | 1.0 |
| RVOT VTI, cm | 0.8 | 1.2 | 0.8 |
| Global RVLSS, % | 1.1 | 1.8 | 1.3 |
| RVSP, mmHg | 6.5 | 2.2 | 6.3 |
| TAPSE to PASP, mm/mmHg | 0.1 | 0.16 | 0.11 |
Abbreviations: TAPSE tricuspid annular plane systolic excursion, FAC fractional area change, S’ tissue Doppler-derived right ventricular systolic excursion velocity, RVOT right ventricular outflow tract, VTI velocity time integral, RVLSS right ventricular longitudinal systolic strain, RVSP right ventricular systolic pressure, PASP pulmonary artery systolic pressure