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. 2022 Jun 18;22:671. doi: 10.1186/s12885-022-09684-0

Table 1.

Summary of half-maximal inhibitory concentrations (μM) of emodin on hepatocyte lines

Cell line L02 HepG2 BEL-7404
Treatment time 24 h 48 h 72 h 24 h 48 h 72 h 24 h 48 h 72 h
IC50 133.05 99.62 73.93 208.71 70.96 52.38 113.57 96.86 46.71
SI* 0.63 1.40 1.52 1.17 1.02 1.58
Cell line QGY-7701 Hep3B BEL-7402
Treatment time 24 h 48 h 72 h 24 h 48 h 72 h 24 h 48 h 72 h
IC50 98.46 71.03 56.99 185.40 115.37 66.11 151.30 84.81 48.09
SI* 1.35 1.40 1.29 0.71 0.86 1.11 0.87 1.17 1.53

*SI Selectivity index, IC50 value against normal liver cells/IC50 value against HCC