Table 3.
Number of cases and controls, odds ratio (OR) and 95% confidence interval (CI) by exposure (ever vs never) and cumulative exposure from SYN-JEM, unlagged and at lag 10, 20 and 30 years, men and women – the MISEM study, 2012–2015, Italy
| Lag 0 | Lag 10 | Lag 20 | Lag 30 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| SYN-JEM exposure | Cases | Ctrls | ORa | CI | ORa | CI | ORa | CI | ORa | CI |
| Ever/never | ||||||||||
| Unexposed | 278 | 446 | 1.00 | (ref) | 1.00 | (ref) | 1.00 | (ref) | 1.00 | (ref) |
| Exposed | 333 | 262 | 2.22 | (1.70–2.91) | 2.21 | (1.69–2.90) | 2.29 | (1.74–3.00) | 2.15 | (1.64–2.82) |
| P-Wald test gender interaction | 0.27 | 0.28 | 0.28 | 0.59 | ||||||
| AIC | 1597.49 | 1595.26 | 1591.05 | 1609.33 | ||||||
| Below/above median cumulative exposure (in f/mL-y) | ||||||||||
| Unexposed | 278 | 446 | 1.00 | (ref) | 1.00 | (ref) | 1.00 | (ref) | 1.00 | (ref) |
| < 0.86 | 120 | 131 | 1.71 | (1.21–2.42) | 1.71 | (1.21–2.42) | 1.84 | (1.30–2.59) | 1.74 | (1.24–2.46) |
| ≥ 0.86 | 213 | 131 | 2.66 | (1.95–3.64) | 2.65 | (1.94–3.61) | 2.68 | (1.96–3.66) | 2.52 | (1.84–3.45) |
| P-trend | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||||||
| P-Wald test gender interaction | 0.46 | 0.48 | 0.47 | 0.76 | ||||||
| AIC | 1593.89 | 1591.87 | 1589.08 | 1607.56 | ||||||
| Tertiles of cumulative exposure (in f/mL-y) | ||||||||||
| Unexposed | 278 | 446 | 1.00 | (ref) | 1.00 | (ref) | 1.00 | (ref) | 1.00 | (ref) |
| < 0.34 | 64 | 87 | 1.35 | (0.88–2.05) | 1.34 | (0.88–2.04) | 1.45 | (0.96–2.21) | 1.21 | (0.79–1.85) |
| 0.34–1.62 | 118 | 87 | 2.52 | (1.75–3.62) | 2.53 | (1.76–3.64) | 2.59 | (1.80–3.73) | 2.48 | (1.72–3.57) |
| > 1.62 | 151 | 88 | 2.65 | (1.85–3.77) | 2.62 | (1.84–3.72) | 2.69 | (1.88–3.83) | 2.64 | (1.85–3.77) |
| P-trend | < 0.001 | < 0.001 | < 0.001 | < 0.001 | ||||||
| P-Wald test gender interaction | 0.39 | 0.36 | 0.30 | 0.58 | ||||||
| AIC | 1591.96 | 1589.78 | 1587.16 | 1601.36 | ||||||
| Cumulative exposure, continuos | ||||||||||
| Unexposed | 278 | 446 | 1.00 | (ref) | 1.00 | (ref) | 1.00 | (ref) | 1.00 | (ref) |
| Unit exposure: 1 f/mL-y | 333 | 262 | 1.28 | (1.16–1.42) | 1.28 | (1.16–1.41) | 1.28 | (1.16–1.42) | 1.31 | (1.18–1.46) |
| AIC | 1603.43 | 1601.83 | 1600.27 | 1612.64 | ||||||
| Log-cumulative exposure, continuos | ||||||||||
| Unexposed | 278 | 446 | 1.00 | (ref) | 1.00 | (ref) | 1.00 | (ref) | 1.00 | (ref) |
| Unit exposure: 1 log(f/mL-y + 1) | 333 | 262 | 2.06 | (1.62–2.61) | 2.05 | (1.61–2.60) | 2.06 | (1.62–2.61) | 2.12 | (1.65–2.72) |
| AIC | 1594.23 | 1592.57 | 1590.98 | 1603.91 | ||||||
AIC Akaike information criterion
aOR adjusted by centre, gender, age and type of interview