Table 3.
Adjusted ORs for AL ≤ 22 mm and AL ≥ 26 mm for Selected Inherited Retinal Diseases Compared With a Reference Cohort (Raine Study)
| AL ≤ 22 mm | AL ≥ 26 mm | ||||
|---|---|---|---|---|---|
| Gene/Condition | n | Adjusted OR (95% CI) | P | Adjusted OR (95% CI) | P |
| ABCA4 | 82 | 0.18 (<0.01–5.92) | 0.334 | 2.15 (0.64–7.24) | 0.215 |
| BCM | 18 | 4.58 (0.35–60.43) | 0.248 | 51.67* (18.58–143.67) | <0.001 |
| BED | 15 | 4.13 (0.23–73.20) | 0.333 | 48.57* (16.27 -145.06) | <0.001 |
| CNGA3 | 28 | 4.10 (0.72–23.18) | 0.111 | 2.83 (0.42–19.02) | 0.285 |
| CNGB3 | 43 | 1.39 (0.10–19.01) | 0.801 | 1.42 (0.18–10.94) | 0.735 |
| RPE65 | 25 | 12.52* (3.90–40.21) | <0.001 | 6.66* (1.82–24.32) | 0.004 |
| RPGR | 60 | 4.56 (0.85–24.47) | 0.077 | 4.88* (1.74–13.72) | 0.003 |
| TYR | 25 | 34.19* (13.20–88.53) | <0.001 | 10.13* (3.06–33.53) | <0.001 |
| OCA2 | 17 | 0.96 (0.01–171.63) | 0.988 | 6.12* (1.18–31.60) | 0.031 |
| GPR143 | 10 | 56.20* (13.05–241.92) | <0.001 | 2.66 (0.18–38.21) | 0.476 |
Firth's logistic regression models were constructed with adjustment for age and sex, related individuals excluded, and models only inclusive of males for BCM, BED, RPGR, and GPR143.
*
Adjusted odds ratios with P < 0.05.