Table 1:
Characteristics of ARIC Study participants in late-life (visit 5, 2011–2013). Data are presented as n (%) or as mean ±S.D.
| Characteristics | Overall | Quartile of 18-year change in FGF23 from midlife to late-life, pg/mL |
|||
|---|---|---|---|---|---|
| Q1: ≤6.4 | Q2: 6.5 to 17.3 | Q3: 17.4 to 31.2 | Q4: ≥31.3 | ||
| n | 5458 | 1364 | 1365 | 1364 | 1365 |
| Age, years | 76 ±5.2 | 75 ± 5.1 | 75 ± 4.9 | 76 ±5.2 | 76 ±5.3 |
| Females | 3172 (58) | 709 (52) | 778 (57) | 817 (60) | 868 (64) |
| Black | 1159 (21) | 333 (24) | 272 (20) | 273 (20) | 281 (21) |
| Ever smoke | 3156 (58) | 817 (60) | 789 (58) | 766 (56) | 784 (57) |
| Systolic BP mmHg | 130 ± 18 | 131± 18 | 130± 18 | 130±18 | 130± 19 |
| Diabetes | 1784 (33) | 435 (32) | 388 (28) | 422 (31) | 539 (40) |
| Medication use | |||||
| Antihypertensive | 4095 (75) | 931 (68) | 953 (70) | 1053 (77) | 1158 (85) |
| Vitamin D | 1501 (28) | 302 (22) | 339 (25) | 397 (29) | 463 (34) |
| Calcium | 1437 (26) | 297 (22) | 333 (24) | 384 (28) | 423 (31) |
| Iron | 232 (4.3) | 62 (4.5) | 45 (3.3) | 46 (3.4) | 79 (5.8) |
| Past medical history | |||||
| Prevalent HF | 692 (13) | 157 (12) | 137 (10) | 168 (12) | 230 (17) |
| Prevalent CHD | 809 (15) | 173 (13) | 190 (14) | 178 (13) | 268 (20) |
| Prevalent stroke | 208 (3.8) | 53 (3.9) | 33 (2.4) | 48 (3.5) | 74 (5.4) |
| Laboratory tests | |||||
| Total cholesterol, mg/dL | 181± 42 | 181± 42 | 183± 41 | 182± 41 | 179± 44 |
| HDL cholesterol, mg/dL | 52± 14 | 52± 14 | 53 ± 14 | 52 ± 13 | 51±13 |
| Calcium, mg/dL | 9.4 ± 0.4 | 9.3± 0.4 | 9.3± 0.4 | 9.4± 0.4 | 9.5± 0.4 |
| Phosphate, mg/dL | 3.5 ± 0.4 | 3.4± 0.4 | 3.4± 0.4 | 3.5 ± 0.4 | 3.6± 0.5 |
| FGF23 at visit 3, pg/mL | 40± 19 | 49 ± 30 | 37± 12 | 36 ± 12 | 38 ± 14 |
| FGF23 at visit 5, pg/mL | 61±26 | 44±16 | 49±12 | 59± 12 | 89±30 |
| eGFR at visit 3, ml/min/1.73m2 | 87± 13 | 86± 13 | 88± 13 | 88± 13 | 86± 14 |
| eGFR at visit 5, ml/min/1.73m2 | 65±18 | 72±16 | 70± 16 | 65± 16 | 55± 18 |
eGFR and FGF23 at visit 3 were based on data in 1993–1995. Between-group difference based on ANOVA or chi-square test was significant (p<0.05) for all variables except for ever smoke (p=0.3), systolic blood pressure (p=0.3), and total cholesterol (p=0.07). To covert to SI units, multiply total cholesterol and HDL cholesterol by 0.026, calcium by 0.250, and phosphate by 0.323. Abbreviations: ARIC, Atherosclerosis Risk in Communities; FGF23, fibroblast growth factor-23; HDL, high-density lipoprotein; eGFR, estimated glomerular filtration rate.