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. Author manuscript; available in PMC: 2022 Jun 18.
Published in final edited form as: Exp Eye Res. 2019 Jan 3;180:200–207. doi: 10.1016/j.exer.2019.01.001

Fig. 10. Schematic representation describing the internalization of EGFR by decorin and EGF induction.

Fig. 10.

Decorin is taken up by the EGFR and the Dcn-EGFR complex is internalized and transferred to the perinuclear vesicles, commonly known as caveosome bypassing the early endosome intake. At this stage, Dcn-EGFR complexes are sent to late endosome (CD63) for final degradation. Conversely, EGF-induces stepwise EGFR endocytosis primarily in early endosome (EEA1), where some part of the EGF-EGFR complex enters the recycling endosome (Rab11) and some portion enters into the late endosome (CD63) for final degradation.