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. Author manuscript; available in PMC: 2022 Jun 18.
Published in final edited form as: Exp Eye Res. 2019 Jan 3;180:200–207. doi: 10.1016/j.exer.2019.01.001

Fig. 7. Decorin-EGFR complex degradation involves late endosome.

Fig. 7.

Human CSFs incubated with rhDcn (A–D) or rhEGF (E–H) and double-immunostained with EGFR (green) and late endosome marker, CD63, (red). Decorin treatment showed high co-localization of EGFR and CD63 in an overlay image (C; yellow, arrows) compared to the rhEGF (G, yellow, arrows). The EGFR staining (green) is shown in panels A and E, and CD63 staining (red) is shown in panels B and F. Schematic diagram shows EGFR internalization target late endosome upon decorin treatment (D) compared to EGF treatment (H). Bar = 10 μM. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)