Table 2.
Toxicity Attributable to Vemurafenib
| Toxicity possibly, probably, or definitely related to vemurafenib | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | Total |
|---|---|---|---|---|---|---|
| Maculopapular rash | 3 | 2 | 5 | |||
| Nausea | 4 | 4 | ||||
| Diarrhea | 2 | 1 | 3 | |||
| Arthralgia | 2 | 1 | 3 | |||
| Alanine aminotransferase elevation | 2 | 2 | ||||
| Alkaline phosphatase elevation | 2 | 2 | ||||
| Fatigue | 2 | 2 | ||||
| Plantar-palmar erythrodysesthesia syndromea | 1 | 1 | 2 | |||
| Pruritus | 2 | 2 | ||||
| Acneiform rash | 2 | 2 | ||||
| Actinic keratosis | 1 | 1 | ||||
| Alopecia | 1 | 1 | ||||
| Anemia | 1 | 1 | ||||
| Anorexia | 1 | 1 | ||||
| Aspartate aminotransferase elevation | 1 | 1 | ||||
| Bloating | 1 | 1 | ||||
| Creatinine increased | 1 | 1 | ||||
| Dehydration | 1 | 1 | ||||
| Dry skin | 1 | 1 | ||||
| Dysgeusia | 1 | 1 | ||||
| Elevated bilirubin | 1 | 1 | ||||
| Fever | 1 | 1 | ||||
| Hoarseness | 1 | 1 | ||||
| Hypophosphatemia | 1 | 1 | ||||
| Mucositis | 1 | 1 | ||||
| Myalgia | 1 | 1 | ||||
| Pain with swallowing | 1 | 1 | ||||
| Watering eyes | 1 | 1 | ||||
| Weight loss | 1 | 1 | ||||
| Hypokalemia | 1 | 1 |
a
Plantar-palmar erythrodysesthesia syndrome is also known as hand-foot syndrome.