Table 3.
Toxicity Attributable to CDX-3379
| Toxicity possibly, probably, or definitely related to CDX-3379 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | Total |
|---|---|---|---|---|---|---|
| Diarrhea | 2 | 1 | 3 | |||
| Nausea | 3 | 3 | ||||
| Arthralgia | 2 | 2 | ||||
| Plantar-palmar erythrodysesthesia syndromea | 1 | 1 | 2 | |||
| Alkaline phosphatase elevation | 2 | 2 | ||||
| Maculopapular rash | 2 | 2 | ||||
| Acneiform rash | 1 | 1 | ||||
| Actinic keratosis | 1 | 1 | ||||
| Anorexia | 1 | 1 | ||||
| Dehydration | 1 | 1 | ||||
| Dysgeusia | 1 | 1 | ||||
| Fever | 1 | 1 | ||||
| Hoarseness | 1 | 1 | ||||
| Pain with swallowing | 1 | 1 | ||||
| Weight loss | 1 | 1 | ||||
| Bloating/PT = abdominal distension | 1 | 1 | ||||
| Hypokalemia | 1 | 1 |
a
Plantar-palmar erythrodysesthesia syndrome is also known as hand-foot syndrome.