Table 7.

Genomic Profiles of the Poorly Differentiated Thyroid Carcinoma and Anaplastic Thyroid Cancer Tumors from Patient 5

Tumor site profiled	Total no. of alterations	BRAFV600E	TERT C228T	9p21 loss	SMO D255N	ARID2 E108*	Other mutations
PDTC (RAI-positive primary)	4	X	X	X	X		None
ATC (RAI-negative pelvic lymph node)	20	X	X	X	X	X	RB1 X738_splice, SOX9 K398N, APC D1570N, CSF1R *973Sext*43, EPHA5 E657K, IDH1 R343K, JAK1 S397C, PTCH1 E1428Q, KMT2D E4781K, NCOA3 H618D, RAD54L E297K, NUP93 E19Q, CDK12 D962H, PBRM1 Q170E, ASXL1 S62C

ATC, anaplastic thyroid carcinoma; PDTC, poorly differentiated thyroid carcinoma; RAI, radioactive iodine.