Table 3.
Univariate Analysis of Factors Associated with Altered PFS and OS on Training Data
| Characteristic | PFS | OS | ||
|---|---|---|---|---|
| 5-year PFS (95% CI) | p-valuea | 5-year OS (95% CI) | p-valuea | |
| HALP cutoff | <0.001 | <0.001 | ||
| ≤22.2 | 46% (39–54%) | 77% (71–84%) | ||
| >22.2 | 71% (68–75%) | 92% (90–95%) | ||
| Age (years) | 0.200 | 0.800 | ||
| <50 | 63% (58–68%) | 89% (86–92%) | ||
| ≥50 | 66% (62–71%) | 89% (86–92%) | ||
| Comorbidities | >0.900 | 0.200 | ||
| No | 65% (62–70%) | 90% (88–93%) | ||
| Yes | 64% (58–70%) | 87% (83–91%) | ||
| BMI (kg/m2) | 0.010 | 0.400 | ||
| Underweight | 53% (41–70%) | 87% (78–97%) | ||
| Normal | 63% (58–68%) | 88% (85–91%) | ||
| Overweight | 69% (65–74%) | 91% (88–94%) | ||
| Stage | <0.001 | <0.001 | ||
| I + II | 76% (72–80%) | 94% (92–96%) | ||
| III | 51% (46–58%) | 83% (79–88%) | ||
| IVA | 23% (10–49%) | 53% (37–76%) | ||
| Histology | 0.007 | 0.500 | ||
| SCC | 68% (64–71%) | 89% (86–91%) | ||
| AD | 57% (49–66%) | 88% (82–94%) | ||
| ASC | 47% (31–73%) | 96% (88–100%) | ||
| Tumor size (cm) | <0.001 | <0.001 | ||
| <4 | 74% (69–79%) | 95% (92–97%) | ||
| 4–8 | 58% (54–63%) | 86% (82–89%) | ||
| >8 | 44% (27–70%) | 81% (68–96%) | ||
| Modalities | <0.001 | <0.001 | ||
| RT | 43% (34–55%) | 76% (67–87%) | ||
| CCRT | 68% (64–71%) | 90% (88–92%) | ||
Note: aLog rank test.
Abbreviations: CI, confidence Interval; BMI, body mass index; SCC, squamous cell carcinoma; AD, adenocarcinoma; ASC, adenosquamous carcinoma; RT, radiation alone; CCRT, concurrent chemoradiation.