Table 4.
Multivariate Analysis of Factors Associated with Altered PFS and OS on Training Data
| Characteristic | PFS | OS | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| HALP cutoff | ||||||
| ≤22.2 | 1.00 | — | 1.00 | — | ||
| >22.2 | 0.55 | 0.43–0.70 | <0.001 | 0.43 | 0.27–0.67 | <0.001 |
| Stage | ||||||
| I + II | 1.00 | — | 1.00 | — | ||
| III | 1.88 | 1.46–2.42 | <0.001 | 2.02 | 1.25–3.25 | 0.004 |
| IVA | 5.18 | 3.18–8.44 | <0.001 | 5.81 | 2.75–12.3 | <0.001 |
| Histology | ||||||
| SCC | 1.00 | — | 1.00 | — | ||
| AD | 1.74 | 1.32–2.31 | <0.001 | 1.18 | 0.67–2.07 | 0.600 |
| ASC | 1.79 | 1.02–3.13 | 0.043 | 0.38 | 0.05–2.72 | 0.300 |
| Tumor size (cm) | ||||||
| <4 | 1.00 | — | 1.00 | — | ||
| 4–8 | 1.30 | 1.00–1.69 | 0.052 | 1.58 | 0.93–2.67 | 0.091 |
| >8 | 1.90 | 1.12–3.24 | 0.018 | 2.14 | 0.84–5.49 | 0.110 |
| Modalities | ||||||
| RT | 1.00 | — | 1.00 | — | ||
| CCRT | 0.55 | 0.41–0.75 | <0.001 | 0.56 | 0.33–0.95 | 0.030 |
Abbreviations: HR, hazard ratio; CI, confidence interval; SCC, squamous cell carcinoma; AD, adenocarcinoma; ASC, adenosquamous carcinoma; RT, radiation alone; CCRT, concurrent chemoradiation.