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. 2022 Jun 18;13(6):555. doi: 10.1038/s41419-022-05006-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A GBM cells (HROG63) were stained with respective antibodies to determine the subcellular localization of cytochrome c (green), calnexin (red), ATF-4 (violet) and counterstained with DAPI to visualize nuclei (blue). CDKi-SpyADI combination resulted in minor UPR. Merged images as well as single images were taken on a Leica DMI 4000B for mitochondrial function/acidic compartment evaluation and ER-stress marker and cytochrome c localization were analyzed via a Zeiss Elyra 7 Confocal Laser Microscope. Representative images are shown. B Quantification of specific markers. n = 3 independent experiments; *p < 0.05, **p < 0.01; ****p < 0.0001; §§§§p < 0.001; $$p < 0.01. One-way ANOVA.