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. 2022 Jun 18;8:293. doi: 10.1038/s41420-022-01082-6

Fig. 3. CC-115 exerts different activity in NSCLC cells and lung epithelial cells.

Fig. 3

pCan2 cells, the immortalized A549 NSCLC cells, the primary human lung epithelial cells (“pEpi”) or the BEAS-2B bronchial epithelial cells were treated with CC-115 (100 nM) and cultivated for the designated time periods; Cell viability (CCK-8 OD, A), cell death (B) and proliferation (by testing the nuclear EdU percentage, C), cell migration (D) and invasion (E) were tested. Cell apoptosis was measured by the nuclear TUNEL staining assay (F) and Annexin V flow cytometry (G). For each assay, n = 5. *P < 0.05 versus “Veh” group. “n.s.” stands for non-statistical difference. Scale bar = 100 μm (D).