Fig. 6. CC-115 oral administration inhibits patient-derived NSCLC xenograft growth in nude mice.

The nude mice bearing pCan1 xenografts were orally administrated with a daily single dose of CC-115 (15 mg/kg) for 15 days or the vehicle control (“Veh”), the estimated tumor volumes A and the animal body weights D were recorded; The estimated daily tumor growth was measured B; At Day-42 tumors were isolated and weighted C. In the described pCan1 xenografts, expression of listed proteins was shown E, G. The relative DNA-PK activity F and the relative TBAR activity H were examined as well. For each assay, n = 5. *P < 0.05 versus “Veh” group.