Table 3.
Relationship between HDL-C and the incident diabetes in different models
| Variable | Crude model (HR.,95% CI, P) | Model I (HR,95% CI, P) |
Model II (HR,95% CI, P) |
GAM (HR,95% CI, P) |
|---|---|---|---|---|
| Total | ||||
| HDL-C | 0.13 (0.09, 0.18) < 0.0001 | 0.34 (0.23, 0.50) < 0.0001 | 0.54 (0.35, 0.82) 0.0044 | 0.47 (0.30, 0.75) 0.0015 |
| HDL-C(quartile) | ||||
| Q1 | ref | ref | ref | ref |
| Q2 | 0.53 (0.42, 0.68) < 0.0001 | 0.68 (0.53, 0.87) 0.0023 | 0.83 (0.64, 1.07) 0.1575 | 0.82 (0.63, 1.06) 0.1343 |
| Q3 | 0.28 (0.20, 0.39) < 0.0001 | 0.44 (0.31, 0.63) < 0.0001 | 0.58 (0.41, 0.83) 0.0031 | 0.54 (0.37, 0.79) 0.0014 |
| Q4 | 0.23 (0.15, 0.34) < 0.0001 | 0.45 (0.30, 0.70) 0.0003 | 0.67 (0.43, 1.05) 0.0791 | 0.58 (0.36, 0.94) 0.0266 |
| P for trend | < 0.0001 | < 0.0001 | 0.0056 | 0.0018 |
| Female | ||||
| HDL-C | 0.14 (0.07, 0.28) < 0.0001 | 0.41 (0.20, 0.84) 0.0155 | 0.92 (0.41, 2.07) 0.8386 | 1.04 (0.44, 2.44) 0.9330 |
| HDL-C(quartile) | ||||
| Q1 | ref | ref | ref | ref |
| Q2 | 0.47 (0.27, 0.81) 0.0070 | 0.67 (0.39, 1.17) 0.1606 | 1.07 (0.58, 1.98) 0.8178 | 1.13 (0.61, 2.06) 0.7021 |
| Q3 | 0.21 (0.11, 0.38) < 0.0001 | 0.41 (0.22, 0.77) 0.0056 | 0.73 (0.36, 1.49) 0.3869 | 0.77 (0.38, 1.55) 0.4589 |
| Q4 | 0.17 (0.09, 0.32) < 0.0001 | 0.43 (0.22, 0.85) 0.0145 | 0.90 (0.41, 1.99) 0.8013 | 1.01 (0.45, 2.28) 0.9841 |
| P for trend | < 0.0001 | 0.0051 | 0.5208 | 0.6933 |
| Male | ||||
| HDL-C | 0.17 (0.11, 0.26) < 0.0001 | 0.32 (0.20, 0.51) < 0.0001 | 0.45 (0.27, 0.76) 0.0030 | 0.37 (0.21, 0.65) 0.0005 |
| HDL-C(quartile) | ||||
| Q1 | ref | ref | ref | ref |
| Q2 | 0.53 (0.40, 0.70) < 0.0001 | 0.66 (0.50, 0.87) 0.0035 | 0.79 (0.59, 1.06) 0.1097 | 0.76 (0.56, 1.02) 0.0713 |
| Q3 | 0.31 (0.20, 0.46) < 0.0001 | 0.46 (0.30, 0.70) 0.0003 | 0.57 (0.37, 0.89) 0.0131 | 0.51 (0.32, 0.82) 0.0052 |
| Q4 | 0.28 (0.16, 0.50) < 0.0001 | 0.50 (0.28, 0.92) 0.0248 | 0.63 (0.34, 1.17) 0.1411 | 0.45 (0.23, 0.88) 0.0200 |
| P for trend | < 0.0001 | < 0.0001 | 0.0080 | 0.0011 |
Crude model: we did not adjust for other covariants
Model I: we adjusted for age, ethanol consumption, smoking, regular exerciser, SBP, DBP, BMI, WC
Model II: we adjusted for age, ethanol consumption, smoking, regular exerciser, SBP, DBP, BMI, WC, TC, TG, HbA1c, FPG
GAM: All covariates listed in Table 1 were adjusted. However, continuous covariates were adjusted as nonlinearity
CI Confidence interval, Ref Reference