Table 3.
Antimicrobial resistance patterns of methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with skin and soft tissue infections grouped by SCCmec type and healthcare exposure status*
| Antimicrobial agents (μg) | HA-SCCmec I/II/III MRSA (n = 125) | HA-SCCmec IV/V MRSA (n = 75) | OR | 95% CI | P† | CA-SCCmec IV/V MRSA (n = 83) | OR‡ | 95% CI‡ | P†‡ |
|---|---|---|---|---|---|---|---|---|---|
| Amikacin | 69 (55·2) | 28 (37·3) | 0·48 | 0·27–0·87 | 0·015 | 4 (4·8) | 11·77 | 3·88–35·63 | <0·001 |
| Gentamicin | 62 (49·6) | 25 (33·3) | 0·51 | 0·28–0·92 | 0·026 | 17 (20·5) | 1·94 | 0·95–3·98 | 0·07 |
| Netilimicin | 23 (18·4) | 10 (13·3) | 0·68 | 0·31–1·53 | 0·35 | 1 (1·2) | 12·62 | 1·57–101·10 | 0·017 |
| Chloramphenicol | 14 (11·2) | 6 (8·0) | 0·69 | 0·25–1·88 | 0·47 | 3 (3·6) | 2·32 | 0·56–9·62 | 0·25 |
| Ciprofloxacin | 91 (72·8) | 42 (56·0) | 0·48 | 0·26–0·87 | 0·016 | 20 (24·1) | 4·01 | 2·03–7·90 | <0·001 |
| Levofloxacin | 87 (69·6) | 40 (53·3) | 0·50 | 0·28–0·90 | 0·022 | 20 (24·1) | 3·60 | 1·83–7·09 | <0·001 |
| Clindamycin | 82 (65·6) | 43 (57·3) | 0·70 | 0·39–1·27 | 0·24 | 17 (20·5) | 5·22 | 2·58–10·53 | <0·001 |
| Co-trimoxazole | 88 (70·4) | 32 (42·7) | 0·31 | 0·17–0·57 | <0·001 | 42 (50·6) | 0·73 | 0·39–1·36 | 0·32 |
| Erythromycin | 106 (84·8) | 53 (70·7) | 0·43 | 0·22–0·87 | 0·018 | 33 (39·8) | 3·65 | 1·88–7·09 | <0·001 |
| Fusidic acid | 25 (20·0) | 14 (18·7) | 0·92 | 0·44–1·90 | 0·82 | 3 (3·6) | 6·12 | 1·68–22·25 | 0·006 |
| Mupirocin | 7 (5·6) | 3 (4·1) | 0·71 | 0·18–2·84 | 0·63 | 0 (0·0) | — | — | 0·064 |
| Rifampicin | 44 (35·2) | 16 (21·3) | 0·50 | 0·26–0·97 | 0·040 | 3 (3·6) | 7·23 | 2·01–25·96 | 0·002 |
| Tetracycline | 87 (69·6) | 34 (45·3) | 0·36 | 0·20–0·66 | 0·001 | 5 (6·0) | 12·94 | 4·70–35·59 | <0·001 |
OR, Odds ratio; CI, confidence interval.
*
According to the CDC definition [7].
†
All P values determined using odds ratios and not derived from t test or χ2 test. P values <0·05 highlighted in bold.
‡
Analyses of antimicrobial resistance patterns of HA-SCCmec-IV/V and CA-SCCmec-IV/V MRSA isolates. All strains were susceptible to vancomycin (screen agar method), linezolid and teicoplanin.
P values <0·05 are highlighted in bold.