Table 2.
Overall and subgroup analyses of the IL-10 −592C/A polymorphism with sepsis susceptibility
| Groups | Studies | Sample size | Test of association | Model | Heterogeneity | |||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | P value | OR (95% CI) | P value | I2 (%) | |||
| Total | ||||||||
| A vs. C | 8 | 778 | 1200 | 0·36 | 0·91 (0·74–1·11) | R | 0·12 | 39 |
| AA vs. CC | 8 | 778 | 1200 | 0·79 | 0·94 (0·60–1·48) | R | 0·20 | 29 |
| AA vs. CC + CA | 8 | 778 | 1200 | 0·56 | 0·92 (0·70–1·22) | R | 0·66 | 0 |
| AA + CA vs. CC | 8 | 778 | 1200 | 0·61 | 0·92 (0·69–1·25) | R | 0·09 | 44 |
| Asian | ||||||||
| A vs. C | 4 | 478 | 507 | 0·95 | 1·01 (0·75–1·36) | R | 0·07 | 57 |
| AA vs. CC | 4 | 478 | 507 | 0·87 | 1·06 (0·55–2·03) | R | 0·07 | 58 |
| AA vs. CC + CA | 4 | 478 | 507 | 0·76 | 0·95 (0·70–1·29) | R | 0·43 | 0 |
| AA + CA vs. CC | 4 | 478 | 507 | 0·59 | 1·15 (0·69–1·94) | R | 0·04 | 64 |
| Caucasian | ||||||||
| A vs. C | 4 | 300 | 693 | 0·05 | 0·78 (0·62–1·00) | R | 0·59 | 0 |
| AA vs. CC | 4 | 300 | 693 | 0·38 | 0·73 (0·36–1·47) | R | 0·59 | 0 |
| AA vs. CC + CA | 4 | 300 | 693 | 0·47 | 0·77 (0·39–1·54) | R | 0·57 | 0 |
| AA + CA vs. CC | 4 | 300 | 693 | 0·05 | 0·75 (0·56–1·00) | R | 0·73 | 0 |
| HWE | ||||||||
| A vs. C | 6 | 509 | 905 | 0·18 | 0·83 (0·64–1·08) | R | 0·12 | 43 |
| AA vs. CC | 6 | 509 | 905 | 0·55 | 0·83 (0·44–1·54) | R | 0·17 | 35 |
| AA vs. CC + CA | 6 | 509 | 905 | 0·60 | 0·90 (0·62–1·32) | R | 0·44 | 0 |
| AA + CA vs. CC | 6 | 509 | 905 | 0·13 | 0·79 (0·58–1·07) | R | 0·23 | 27 |
| Sepsis | ||||||||
| A vs. C | 7 | 662 | 1059 | 0·31 | 0·89 (0·70–1·12) | R | 0·08 | 46 |
| AA vs. CC | 7 | 662 | 1059 | 0·87 | 0·96 (0·56–1·63) | R | 0·14 | 38 |
| AA vs. CC + CA | 7 | 662 | 1059 | 0·56 | 0·94 (0·70–1·25) | R | 0·56 | 0 |
| AA + CA vs. CC | 7 | 662 | 1059 | 0·50 | 0·89 (0·63–1·25) | R | 0·08 | 47 |
OR, Odds ratio; CI, confidence interval; HWE, Hardy–Weinberg equilibrium.