Table 4.
Overall and subgroup analyses of the IL-10 −1082A/G polymorphism with sepsis susceptibility
| Groups | Studies | Sample size | Test of association | Model | Heterogeneity | |||
|---|---|---|---|---|---|---|---|---|
| Cases | Controls | P value | OR (95% CI) | P value | I2 (%) | |||
| Total | ||||||||
| G vs. A | 18 | 1497 | 2228 | 0·31 | 1·13 (0·89–1·44) | R | <0·00 001 | 76 |
| GG vs. AA | 18 | 1497 | 2228 | 0·64 | 0·91 (0·61–1·35) | R | 0·008 | 53 |
| GG vs. AA + AG | 19 | 1513 | 2254 | 0·08 | 0·83 (0·68–1·02) | R | 0·65 | 0 |
| GG + AG vs. AA | 19 | 1535 | 2249 | 0·52 | 1·10 (0·82–1·47) | R | <0·0001 | 65 |
| Asian | ||||||||
| G vs. A | 5 | 354 | 468 | 0·03 | 1·41 (1·04–1·91) | R | 0·25 | 25 |
| GG vs. AA | 5 | 354 | 468 | 0·58 | 1·64 (0·29–9·41) | R | 0·02 | 81 |
| GG vs. AA + AG | 5 | 354 | 468 | 0·36 | 0·79 (0·48–1·31) | R | 0·67 | 0 |
| GG + AG vs. AA | 5 | 354 | 468 | 0·03 | 2·11 (1·07–4·16) | R | 0·006 | 73 |
| Caucasian | ||||||||
| G vs. A | 13 | 1143 | 1760 | 0·82 | 1·03 (0·77–1·39) | R | <0·00 001 | 81 |
| GG vs. AA | 13 | 1143 | 1760 | 0·31 | 0·82 (0·57–1·19) | R | 0·07 | 39 |
| GG vs. AA + AG | 14 | 1159 | 1786 | 0·15 | 0·85 (0·69–1·06) | R | 0·56 | 0 |
| GG + AG vs. AA | 14 | 1181 | 1781 | 0·34 | 0·88 (0·67–1·15) | R | 0·04 | 44 |
| HWE | ||||||||
| G vs. A | 15 | 1296 | 1980 | 0·6 | 1·08 (0·82–1·42) | R | <0·00 001 | 78 |
| GG vs. AA | 15 | 1296 | 1980 | 0·10 | 0·75 (0·54–1·06) | R | 0·19 | 26 |
| GG vs. AA + AG | 15 | 1296 | 1980 | 0·06 | 0·80 (0·64–1·01) | R | 0·64 | 0 |
| GG + AG vs. AA | 15 | 1296 | 1980 | 0·84 | 0·97 (0·75–1·26) | R | 0·02 | 48 |
| Sepsis | ||||||||
| G vs. A | 15 | 1315 | 1958 | 0·35 | 1·13 (0·88–1·46) | R | <0·00 001 | 75 |
| GG vs. AA | 15 | 1315 | 1958 | 0·36 | 0·87 (0·63–1·18) | R | 0·23 | 21 |
| GG vs. AA + AG | 16 | 1331 | 1984 | 0·17 | 0·86 (0·69–1·07) | R | 0·75 | 0 |
| GG + AG vs. AA | 16 | 1353 | 1979 | 0·92 | 0·99 (0·81–1·21) | R | 0·21 | 22 |
OR, Odds ratio; CI, confidence interval; HWE, Hardy–Weinberg equilibrium.