Table 3.
Distribution of genotype and allele frequencies of IL-10 in controls (n = 150) and HCV patients (n = 150)
| Genotype | Controls n (%) | Patients n (%) | Crude OR (95% CI) | P value | Adjusted OR† (95% CI) | P value | Allele frequency | |
|---|---|---|---|---|---|---|---|---|
| Controls | Patients | |||||||
| IL-10 –1082A/G (MnII) | ||||||||
| AA | 85 (56%) | 64 (42%) | 1 (Ref.) | 1 (Ref.) | 0·75 | 0·65 | ||
| AG | 55 (36·5%) | 67 (44·5%) | 1·6 (0·99–2·62) | 0·05* | 1·65 (1·02–2·68) | 0·04* | ||
| GG | 10 (7·5%) | 19 (12·5%) | 2·5 (1·09–5·79) | 0·025* | 2·6 (1·17–6·09) | 0·015* | 0·25 | 0·35 |
| IL-10 –1082A/G (MnII) | ||||||||
| CC | 57 (38%) | 48 (32%) | 1 (Ref.) | 1 (Ref.) | 0·63 | 0·58 | ||
| CT | 75 (50%) | 79 (53%) | 1·2 (0·76–2·05) | 0·37 | 1·3 (0·79–2·0) | 0·35 | ||
| TT | 18 (12%) | 23 (15%) | 1·5 (0·73–3·13) | 0·25 | 1·5 (0·75–3·22) | 0·24 | 0·37 | 0·42 |
| IL-10 –592A/C (RsaI) | ||||||||
| AA | 32 (21%) | 28 (18·5%) | 1 (Ref.) | 1 (Ref.) | 0·36 | 0·31 | ||
| AC | 45 (30%) | 36 (24%) | 0·91 (0·46–1·79) | 0·79 | 0·97 (0·49–1·89) | 0·88 | ||
| CC | 73 (49%) | 86 (57·5%) | 1·35 (0·74–2·44) | 0·32 | 1·37 (0·77–2·51) | 0·29 | 0·64 | 0·69 |
Ref., Reference category; OR, Odds ratio; CI, confidence interval.
†
OR adjusted with multivariate logistic regression models.
*
P < 0·05 is considered statistically significant.