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. 2022 Jun 12;2022:6130806. doi: 10.1155/2022/6130806

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Copyright © 2022 Yuanyuan Lyu et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

HK2 was regulated by miR-200 and silencing of HK2 abolishes the effects of miR-200 in OC cell lines. (a) Analysis of TargetScan, Pictar, and miRBase datasets identified 21 genes as potential target of miR-200. (b) Assay of dual-luciferase reporter was performed to explore the binding relationship between miR-200 and HK2 in 293T cells. (c) The expression of HK2 in OC cells with si-miR-200. (d) Effect of reintroduction of HK2 on miR-200-mimics cell proliferation by CCK-8 assay; (e) Effect of reintroduction of HK2 on miR-200-mimics invasion ability by transwell assay; (f) The oxygen consumption rate was analyzed after transfection of OC cells. ^∗∗P < 0.01.