Table 1.
Physical and clinical parameters of subjects enrolled in the study*.
| Physical and clinical parameters | Controls (N = 23; F = 16) | LD (w/o FPLD1) (N = 32; F = 24) | Obese (N = 13; F = 8) | Multiple Comparisons Result |
|---|---|---|---|---|
| Age (years) | 34.5 ± 3.9 | 35.0 ± 3.4 | 49.1 ± 3.5 | ns |
| BMI (Kg/m2) | 21.2 ± 0.6 | 20.6 ± 0.7 | 43.5 ± 1.7 | a ns; b ****; c **** |
| Glucose (mg/dL) | 91.0 ± 2.0 | 94.0 ± 3.3 | 111.7 ± 7.3 | ns |
| TG (mg/dL) | 80.8 ± 9.2 | 153.6 ± 27.3 | 154.1 ± 13.4 | a **; b ***; c ns |
| Chol (mg/dL) | 180 ± 7.6 | 169.8 ± 5.7 | 198.8 ± 10.0 | a ns; b ns; c * |
| HDL-C (mg/dL) | 65.4 ± 3.7 | 45.25 ± 2.7 | 47.5 ± 3.2 | a ***; b *; c ns |
| LDL-C (mg/dL) | 106.3 ± 7.1 | 113.7 ± 5.2 | 137.7 ± 8.7 | a ns; b *; c ns |
| CRP (mg/L) | 0.05 ± 0.01 | 0.7 ± 0.2 | 0.88 ± 0.16 | a **; b ****; c ns |
| AST/GOT (U/L) | 18.8 ± 0.8 | 28.1 ± 2.1 | 36.4 ± 7.3 | a**; b*; c ns |
| ALT/GPT (U/L) | 13.5 ± 1.0 | 34.4 ± 4.6 | 55.9 ± 13.3 | a****; b****; c ns |
| GGT (U/L) | 11.8 ± 1.4 | 28.4 ± 4.1 | 59.3 ± 16.0 | a **; b****; c ns |
| LD Subtype | 11 FPL (of which 8 FPLD2) 12 APL 9 CGL |
a = Controls vs. LD; b= Controls vs. Obese; c = LD vs. Obese. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data are expressed as Mean ± SEM. ns, not significant.