Figure 1.

Diffuse large B-cell lymphoma and classical Hodgkin’s lymphoma diagnosis on lymph node biopsy. Large lymphoid cells with basophil cytoplasm, ovalar nuclei, and one or more nucleoli; small lymphocytes with a round nucleus were visible among the more numerous large cells (A, hematoxylin and eosin). The large cells were positive for CD20 (B) and BCL2 (C). CD5 was strongly positive in the small cells, while the large cells were partially and weakly positive (D). Large pleomorphic cells, with one or two ovalar nuclei and macro-nucleoli in a background of small lymphocytes and granulocytes with fibrosis (E, hematoxylin and eosin). The large cells were positive for CD30 (F) and PAX5 (H). Immunohistochemical staining for EBV-encoded RNA (EBER) was positive (G). (A, C, D–H: original magnification ×40; B: original magnifications ×20).