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. 2022 Jun 6;13:889032. doi: 10.3389/fphys.2022.889032

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Copyright © 2022 Schranc, Fodor, Südy, Tolnai, Babik and Peták.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Peak inspiratory pressure (PIP), airway and viscoelastic respiratory tissue mechanical parameters obtained during volume-controlled ventilation with physiological parameters (NV) and injurious ventilation in control rats (CTRL), in rats with metformin-treated type 2 diabetes (MET), and in rats with untreated type 2 diabetes (T2DM). (A) : Absolute changes in mean values ±standard deviation (SD). (B) : Changes after 4 h of injurious ventilation values relative to the values obtained at 0 h. *p < 0.05 vs. 0 h; #p < 0.05 vs. 2 h; $p < 0.05 vs. CTRL; §p < 0.05 vs. MET. Abbreviations: PIP, Peak inspiratory pressure; Raw, airway resistance; G, tissue damping (resistance); H, tissue elastance.