Fig. 3.

Functional analysis of the R-methyl-protein network.A, protein clusters identified in the Reactome functional interaction network of R-methyl-proteins. Node size is proportional to the number of methyl-sites annotated on that protein; red borders highlight proteins bearing regulated methyl-sites. B, top five most enriched functional GO terms per each protein cluster. C, topology analysis performed on the Reactome interaction network displaying the increase in degree and centrality of proteins with increasing numbers of R-methyl-sites (p values are calculated with Mann–Whitney test). GO, Gene Ontology.