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. 2022 May 14;21(7):100243. doi: 10.1016/j.mcpro.2022.100243

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Functional analysis of dynamically regulated R methylations.A, topology analysis performed on the Reactome network reveals that proteins bearing at least one significantly regulated R-methyl-site have significantly higher degree and network centrality than those without regulated R-methyl-sites (p values are calculated with Mann–Whitney test). B, functional enrichment performed on proteins bearing at least one regulated R-methyl-site (top) or no regulated R-methyl-sites (bottom). C, intersection of PhaSepDB and ProMetheusDB shows that 60% of R-methyl-proteins are involved in the process of liquid–liquid phase separation (LLPS). D, motif analysis performed on significantly regulated (top) and unchanging (bottom) R-sites. Logos were generated using the full list of identified methyl-sites as background.