Table 2.
Lipid classes assessed by targeted lipidomics: concentration (pmol/mL), range of concentration (maximum and minimum, pmol/mL) and associations with EAT volume.
| Lipid class name | Class abbreviation | Concentration | Minimum | Maximum | No. of species | No. of species* |
|---|---|---|---|---|---|---|
| Acylcarnitine | AC | 780.16 | 277.75 | 1,897.03 | 28 | 4 |
| Alkenylphosphatidylcholine (P) | PC(P) | 60,236.05 | 25,391.79 | 128,139.69 | 30 | 0 |
| Alkenylphosphatidylethanolamine (P) | PE(P) | 63,098.10 | 22,049.00 | 157,529.53 | 53 | 0 |
| Alkyldiacylglycerol | TG(O) | 2,225.81 | 526.33 | 17,015.81 | 20 | 12 |
| Alkylmonoacylglycerol | DG(O) | 1,931.96 | 442.86 | 5,054.66 | 2 | 0 |
| Alkylphosphatidylcholine | PC(O) | 71,020.49 | 35,800.19 | 125,404.02 | 34 | 0 |
| Alkylphosphatidylethanolamine | PE(O) | 3,595.49 | 1,510.84 | 7,742.28 | 14 | 0 |
| Bile acid | BA | 835.86 | 115.07 | 6,533.81 | 2 | 0 |
| Ceramide | Cer(d) | 18,222.47 | 5,289.50 | 35,327.51 | 47 | 8 |
| Ceramide-1-phosphate | C1P | 5.95 | 0.96 | 17.30 | 1 | 0 |
| Cholesteryl ester | CE | 3,481,161.11 | 1,801,143.14 | 6,008,721.67 | 27 | 2 |
| Dehydrocholesterol ester | DE | 18,330.58 | 7,819.13 | 61,318.78 | 6 | 1 |
| Dehydrodemosterol ester | deDE | 360.13 | 23.77 | 5,225.42 | 2 | 0 |
| Deoxyceramide | Cer(m) | 1,337.83 | 258.05 | 7,013.12 | 11 | 8 |
| Diacylglycerol | DG | 113,181.88 | 37,769.76 | 432,782.54 | 26 | 14 |
| Dihexosylceramide | Hex2Cer | 4,007.89 | 1,549.11 | 7,162.76 | 10 | 0 |
| Dihydroceramide | dhCer | 375.41 | 149.99 | 777.79 | 6 | 2 |
| Dimethyl-cholesteryl ester | dimethyl-CE | 24,635.70 | 7,573.76 | 71,080.92 | 4 | 0 |
| Free cholesterol | COH | 747,839.09 | 428,202.30 | 1,178,895.10 | 1 | 0 |
| Free fatty acid | FFA | 395,032.85 | 205,376.16 | 683,429.45 | 17 | 0 |
| GD1 ganglioside | GD1 | 7.36 | 1.84 | 14.66 | 1 | 0 |
| GM1 ganglioside | GM1 | 19.03 | 0.61 | 41.33 | 1 | 0 |
| GM3 ganglioside | GM3 | 3,121.22 | 1,384.39 | 5,629.32 | 7 | 0 |
| Hydroxylated acylcarnitine | AC-OH | 23.52 | 9.22 | 46.06 | 8 | 5 |
| Lysoalkenylphosphatidylcholine (P) | LPC(P) | 772.16 | 198.42 | 1,508.36 | 6 | 0 |
| Lysoalkenylphosphatidylethanolamine (P) | LPE(P) | 310.79 | 102.04 | 745.05 | 4 | 0 |
| Lysoalkylphosphatidylcholine (LAF) | LPC(O) | 3,094.26 | 1,333.28 | 4,890.32 | 10 | 0 |
| Lysophosphatidylcholine | LPC | 219,759.08 | 115,804.17 | 370,825.40 | 61 | 3 |
| Lysophosphatidylethanolamine | LPE | 6,563.27 | 3,124.24 | 12,965.85 | 14 | 0 |
| Lysophosphatidylinositol | LPI | 1,519.93 | 844.58 | 2,776.85 | 7 | 2 |
| Methyl-cholesteryl ester | methyl-CE | 37,950.13 | 10,953.57 | 129,335.37 | 5 | 0 |
| Methyl-dehydrocholesteryl ester | methyl-DE | 2,929.83 | 622.81 | 9,579.89 | 2 | 0 |
| Monohexosylceramide | HexCer | 3,212.20 | 911.79 | 6,392.99 | 14 | 0 |
| Oxidized lipids | OxSpecies | 6,579.85 | 2,681.95 | 13,155.84 | 6 | 1 |
| Phosphatidic acid | PA | 76.43 | 40.32 | 164.48 | 5 | 0 |
| Phosphatidylcholine | PC | 1,737,177.86 | 1,048,144.69 | 2,398,255.66 | 90 | 4 |
| Phosphatidylethanolamine | PE | 40,484.40 | 15,353.48 | 95,420.85 | 37 | 5 |
| Phosphatidylglycerol | PG | 475.99 | 134.61 | 1,170.81 | 3 | 1 |
| Phosphatidylinositol | PI | 215,820.31 | 60,717.32 | 370,648.86 | 27 | 9 |
| Phosphatidylinositol monophosphate | PIP1 | 628.26 | 85.24 | 1,380.75 | 1 | 0 |
| Phosphatidylserine | PS | 6,981.00 | 354.86 | 23,312.22 | 7 | 0 |
| Sphingomyelin | SM | 342,792.34 | 190,455.47 | 557,621.10 | 47 | 2 |
| Sphingosine | Sph | 494.68 | 214.47 | 1,108.70 | 1 | 0 |
| Sphingosine-1-phosphate | S1P | 2,072.79 | 1,120.77 | 4,252.17 | 4 | 0 |
| Sulfatide | SHexCer | 565.90 | 269.16 | 1,082.07 | 6 | 0 |
| Triacylglycerol (NL) | TG | 1,742,464.14 | 450,098.99 | 7,784,888.83 | 77 | 51 |
| Trihexosylcermide | Hex3Cer | 1,580.81 | 739.32 | 2,721.76 | 6 | 0 |
| Ubiquinone | Ubiquinone | 2,069.76 | 508.35 | 4,924.12 | 1 | 1 |
| Total | 799 | 135 |
Numeric values are given as average and range. No., number; P, Plasmogen; LAF, lysoplatelet activating factor.
*
No. with p < 0.05 designates the number of lipids significantly associated with EAT volume measurement at the 0.05 level of false discovery rate (FDR) under adjustment for age, sex and their interactions.