Table 1.
Patients' characteristics at inclusion.
| Patients' characteristics | Whole cohort | |
|---|---|---|
| N = 99 (%) | ||
| General | ||
| Mean age (years) | 64 | |
| Male gender | 51 (52%) | |
| Risk factor | Smoking | |
| No | 10 (10%) | |
| Cessation >3years | 40 (40%) | |
| Current | 49 (49%) | |
| Preexisting cardiovascular diseases | ||
| Coronary artery disease | 14 (14%) | |
| Other artery disease | 11 (11%) | |
| Arrhythmia/Conduction abnormality | 13 (13%) | |
| Heart failure | ||
| LVEF <40% | 1 (1%) | |
| LVEF 40–50% | 6(6%) | |
| LVEF >50% | 8(8%) | |
| Cardiovascular risk factors | ||
| Age (male >50 years; female >60 years) | 80 (81%) | |
| Diabetes mellitus | 19 (19%) | |
| Dyslipidaemia | 32 (32%) | |
| Hypertension | 18 (18%) | |
| Primary cancer type | Adenocarcinoma | 65 (66%) |
| Squamous cell carcinoma | 17 (17%) | |
| Small cell lung cancer | 12 (12%) | |
| Others | 5 (5%) | |
| Pre-ICI biomarkers | Positive serum troponin before ICI | 6 (6%) |
| Troponin (ng/l) | 13+/−21μ | |
| BNP (pg/ml) | 44+/−41π | |
| NT-pro-BNP (pg/ml) | 341+/−448Ω | |
| CPK (UI/l) | 64+/−55† | |
| Pre-ICI ECG | PR (ms) | 153+/−27‡ |
| QRS (ms) | 94+/−21
|
|
| Pre-ICI TTE | LVEG (%) | 61%+/−6.5%
|
| Strain (%) | −18%+/−3.1%
|
|
| S'VD (cm/s) | 13.6+/−2.66
|
Missing data :
μ
= 8 (8%),
π
= 25 (25%),
†
= 14 (14%),
‡
= 11 (11%),
=9 (9%), = 2 (2%), = 39 (39%), = 14 (14%)Patients concerned :
Ω
= 15 (15%).
ECG, electrocardiogram; ICI, Immune checkpoint inhibitors; TTE, Transthoracic echocardiogram; LVEG, Left ventricular ejection fraction.
Data were expressed as mean +/- standard deviation, as appropriate.