Table 4.
Independent associations between eGFR values (included as a continuous measure) and plasma levels of either PIIINP (model 1) or HA (model 2), adjusted for age, sex, systolic blood pressure, PNPLA3 rs738409 genotype, and stages of liver fibrosis in children with NAFLD.
| Linear regression analysis | Std. beta coefficient | SE | P-value |
|---|---|---|---|
| eGFRBedsideSchwartz (ml/min/1.73 m2) | |||
| Adjusted model 1 | |||
| PIIINP (ng/ml) | −0.206 | 0.65 | 0.011 |
| Age (years) | −0.222 | 0.88 | 0.066 |
| Sex (M vs. F) | −0.027 | 4.7 | 0.798 |
| Systolic blood pressure (mmHg) | 0.128 | 0.20 | 0.306 |
| PNPLA3 rs738409 | |||
| CC genotype (n = 31) | Ref. | ||
| CG genotype (n = 40) | −0.204 | 2.7 | 0.107 |
| GG genotype (n = 35) | −0.334 | 3.0 | 0.021 |
| Liver fibrosis, any stage (F0 vs. F ≥ 1) | −0.018 | 4.5 | 0.883 |
| Adjusted model 2 | |||
| HA (ng/ml) | −0.531 | 0.57 | <0.0001 |
| Age (years) | −0.185 | 0.85 | 0.101 |
| Sex (M vs. F) | 0.064 | 4.4 | 0.517 |
| Systolic blood pressure (mmHg) | 0.181 | 0.18 | 0.202 |
| PNPLA3 rs738409 | |||
| CC genotype (n = 31) | Ref. | ||
| CG genotype (n = 40) | −0.191 | 2.4 | 0.108 |
| GG genotype (n = 35) | −0.248 | 3.1 | 0.068 |
| Liver fibrosis, any stage (F0 vs. F ≥ 1) | 0.160 | 4.7 | 0.204 |
Data are expressed as standardized beta coefficients as tested by multivariable linear regression analysis.
eGFR, glomerular filtration rate; PIIINP, N-terminal propeptide of type III procollagen; HA, hyaluronic acid, Ref., reference category. The bold values indicate the significant p values.