Figure 4.

The role of BMAL1 in the genotoxic stress response. The effect of BMAL1 in the genotoxic stress response involves regulation of the DDR pathway and cell cycle (G1/S transition and G2/M transition). BMAL1 regulates the key DSB detection and signaling gene ATM by directly binding to the ATM promoter region. At the bottom of the DDR cascade, BMAL1 regulates p53 by binding to the p53 gene promoter region and transcriptionally activating p53 phosphorylation. BMAL1 regulates some key molecules in the G1/S transition such as p21, Cdk4/6, and Cyclin D. BMAL1 regulates some key molecules in the G2/M transition such as Wee1, cdc2 and Cylin B.