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. 2022 Apr 8;113(6):2129–2143. doi: 10.1111/cas.15349

FIGURE 5.

FIGURE 5

Effects of acetyl‐coenzyme A:cholesterol acetyltransferase and scavenger receptor class B member I inhibitors on lymphoma cell proliferation during incubation with lipoproteins. (A) Proliferation of activated T cells and lymphoma cells following incubation with or without low‐density lipoprotein (LDL) (40 µg/ml) for 24 h. (B) Total cholesterol (chol) and free cholesterol of ED cells following incubation with LDL (40 μg/ml) in the presence of CI‐976 and/or BLT‐1 for 24 h. (C) Proliferation of lymphoma cells following incubation with both CI‐976 (10 µM) and BLT‐1 (10 µM) in the presence of LDL for 24 h. (D) Proliferation of lymphoma cells following incubation with CI‐976 (10 µM) in the presence of high‐density lipoprotein (HDL) (40 µg/ml) for 48 h. (E) Proliferation of activated T cells and lymphoma cells following incubation with HDL (40 µg/ml) for 48 h. (F) Proliferation of lymphoma cells following incubation with BLT‐1 (10 µM) in the presence of HDL (40 µg/ml) for 48 h. Data are presented as mean ± SD. #p‐value <0.05, *p‐value <0.05 compared with untreated controls