FIGURE 7.

Hepatocellular carcinoma (HCC)‐derived exosomal circGSE1 facilitates HCC progression in vitro and in vivo via inducing the expansion of Tregs. A, B, Migration and invasion capacity of Huh7 cells cocultured with T cells subject to indicated treatment detected by Transwell. C, D, Scratch wound healing assays in Huh7 cells cocultured with T cells subject to indicated treatment. E, F, Bioluminescence imaging of C57 mice after tail vein injection of HCC cells mixed with HCC‐exo–induced T cells, or T cells induced by HCC‐exo that had been transfected with NC‐overexpression (OE)/circGSE1‐OE (n = 3/per group). Metastasis was monitored by bioluminescence using an in vivo imaging system. All data are means ± SD; n = 3, *p < 0.05, **p < 0.01, ***p < 0.001