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. 2022 Jun 6;13:874211. doi: 10.3389/fneur.2022.874211

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Copyright © 2022 Kim, Rebman, Johnson, Wang, Yang, Colantuoni, Bhargava, Levy, Calabresi, Aucott, Soloski and Darrah.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-PAD2 antibody levels by MS subtype and disease severity. (A) Scatterplot showing the multiple sclerosis severity score (MSSS) plotted against anti-PAD2 arbitrary units (AU) of all comers with MS with available clinical data (n = 88). A univariate analysis was performed between MSSS and anti-PAD2 AU and the Kendall's Tau correlation coefficient (T), p-value, trendline (solid black line), and 95% confidence intervals (dotted black lines) are shown. (B) Anti-PAD2 Arbitrary Units (AU) in people with RRMS (n = 41), SPMS (n = 31), and PPMS (n = 16) were plotted and compared using a Kruskal–Wallis test adjusted for multiple comparisons. The median and 95% confidence interval are shown. **p < 0.01.