FIGURE 3.

Histopathological score as assessed after haematoxylin-eosin staining in lung tissue from ventilated control (CTL, n = 6) animals and piglets submitted to meconium aspiration (MAS) and then treated with i.v. vehicle (VEH, n = 10) or CBD (n = 6). Top: Representative light microphotographs. In lung from MAS-VEH animals there is interstitial leukocyte infiltration, haemorrhage and interstitial oedema, which was reduced by CBD treatment. Original magnification x200, bar: 200 μm. Bottom: quantification of lung damage by a severity score. Results are expressed as mean ± SEM of 6–10 animals. (*) p < 0.05 vs. CTL, (#) p < 0.05 vs. MAS + VEH by one-way ANOVA with Holm-Šidák’s post-hoc test for multiple comparisons.