TABLE 1.
Haemodynamic and ventilator parameters.
| Parameter measured | CTL (n = 6) |
MAS + VEH (n = 10) | MAS + CBD (n = 6) | 2-way ANOVA | |
| Haemodynamics | |||||
| CO (mL/Kg/min) | B | 335.6 (29.1) | 344.8 (18.5) | 325.3 (21.9) | Time: p = 0.37 |
| T | 360.1 (22.3) | 368.3 (16.0) | 320.3 (26.5) | Group: p = 0.05 | |
| 1 | 356.8 (26.7) | 364,0 (22.0) | 345.2 (34.0) | Interact: p = 0.9 | |
| 3 | 297.5 (25.2) | 378.4 (23.8) | 321.6 (32,5) | ||
| 6 | 309.6 (26.7) | 298.3 (31.9) | 306.5 (43.5) | ||
| * | * # | ||||
| Heart rate (bpm) | B | 160 (12) | 193 (15) | 201 (16) | Time:, p = 0.24 |
| T | 177 (16) | 215 (11) | 225 (10) | Group: p = 0.00003 | |
| 1 | 177 (16) | 221 (8) | 249 (12) | Interact: p = 0.47 | |
| 3 | 175 (11) | 209 (9) | 249(10) | ||
| 6 | 183 (13) | 180 (11) | 239(13) | ||
| Ventilation | |||||
| * | * | ||||
| FiO2 | B | 0.22 (0.01) | 0.22 (0.008) | 0.24 (0.02) | Time:, p = 0.0002 |
| T | 0.22 (0.05) | 0.56 (0.09) | 0.51 (0.05) | Group: p = 0.01 | |
| 1 | 0.23 (0.04) | 0.49 (0.07) | 0.44 (0.07) | Interact: p = 0.99 | |
| 3 | 0.24 (0.06) | 0.56 (0.09) | 0.46 (0.07) | ||
| 6 | 0.27 (0.08) | 0.66 (0.11) | 0.56 (0.12) | ||
| * | |||||
| SO2 (%) | B | 96.7 (0.8) | 97.2 (0.6) | 97.2 (1.0) | Time: p = 0.01 |
| T | 96.2 (0.9) | 93.4 (0.7) | 93.8 (0.9) | Group: p = 0.01 | |
| 1 | 96.5 (0.8) | 94.2 (1.0) | 97.8 (0.5) | Interact: p = 0.78 | |
| 3 | 98.5 (0.9) | 92.2 (1.3) | 94.5 (1.7) | ||
| 6 | 94.2 (0.8) | 81.3 (5.1) | 90.1 (4.4) | ||
| * | * | ||||
| MAP (cm H2O) | B | 7.2 (0.6) | 7.8 (0.3) | 8.4 (0.4) | Time: p = 0.00002 |
| T | 7.3 (0.7) | 10.8 (0.05) | 9.5 (0.4) | Group: p = 0.01 | |
| 1 | 7.4 (0.4) | 11.1 (0.5) | 9.1 (0.4) | Interact, p = 0.92 | |
| 3 | 7.3 (0.6) | 11.2 (0.5) | 10.0 (0.8) | ||
| 6 | 7.9 (0.8) | 13 (1.0) | 11.9 (2.3) | ||
| Ventilator rate (bpm) | B | 31.5 (1.7) | 31.3 (1.3) | 30.6 (1.6) | Time: p = 0.01 |
| T | 32.3 (2.5) | 31.3 (1.6) | 30.8 (1.2) | Group: p = 0.88 | |
| 1 | 32.8 (3.1) | 33.5 (1.8) | 30.8 (1.2) | Interact: p = 0.59 | |
| 3 | 32.3 (2.5) | 32.8 (1.7) | 33.3 (3.1) | ||
| 6 | 32.3 (2.5) | 35.2 (2.3) | 35.3 (3.3) | ||
| PEEP (cmH2O) | B | 5.0 (0) | 5.0 (0) | 5.0 (0) | Time: p = 0.0001 |
| T | 5.0 (0) | 5.1 (0.1) | 5.1 (0.1) | Group: p = 0.27 | |
| 1 | 5.0 (0) | 5.1 (0.1) | 5.1 (0.1) | Interact: p = 0.16 | |
| 3 | 5.0 (0) | 5.4 (0.3) | 5.3 (0.3) | ||
| 6 | 5.0 (0) | 5.8 (0.3)* | 5.7 (0.4)* | ||
| * | * | ||||
| OI (ratio) | B | 1.5 (1.0) | 1.6 (0.8) | 1.7 (0.7) | Time: p = 0.0002 |
| T | 1.5 (0.8) | 7.1 (1.4) | 6.5 (1.2) | Group: p = 0.003 | |
| 1 | 1.5 (0.9) | 6.4 (1.2) | 4.8 (1.3) | Interact: p = 0.99 | |
| 3 | 1.4 (1.9) | 8.9 (2.1) | 5.5 (1.3) | ||
| 6 | 1.9 (0.9) | 12.6 (3.4) | 10.9 (3.9) | ||
Mean (SEM). B, basal; T, moment at which the treatment (VEH, vehicle; CBD, cannabidiol 5 mg/kg) was administered. 1, 3, 6: hours after meconium aspiration (MA). CO, cardiac output; SO2, arterial oxygen saturation; FiO2, oxygen fraction in the inspired air; MAP, mean airway pressure; OI, oxygenation index. (*) P < 0.05 vs. CTL, (#) p < 0.05 vs. MAS + VEH, all by two-way ANOVA with Holm-Šidák’s post-hoc test for multiple comparisons.