Table 2.
Comparison of the main murine and porcine LN differences.
| Murine LN | Porcine LN | ||
|---|---|---|---|
| Lymph flow | Centripetal | Centrifugal | |
| Afferent lymphatic | Side in contact with pfMθ |
Floor of the
scSinus (39) |
pfLymph |
| Side in contact with TZ |
Floor of the scSinus
Lyve-1pos (25) |
Ceiling of the affLymph
Lyve-1pos |
|
| Side opposed to TZ |
Ceiling of the scSinus
Lyve-1neg (25) |
Floor of the affLymph
Lyve-1neg |
|
| Connection with blood |
Collagen conduits connecting scSinus to
HEV (5, 35) |
pfLymph connecting to
post-HEV capillaries |
|
| B cell follicles | Subcapsular/Peripheral | Core/Central | |
| Efferent area | Core/central | Subcapsular | |
| Mature B cell exit | Efferent lymphatic | Post-HEV venules |
LN, Lymph Node; pfMθ, perifollicular macrophages (murine subcapsualr sinus macrophages); scSinus, subcapsular sinus; pfLymphatic, perifollicular lymphatics; affLymph, afferent lymphatics; TZ, T cell Zone; HEV, High Endothelial Venule.