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. 2022 Jun 6;13:853113. doi: 10.3389/fgene.2022.853113

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Copyright © 2022 Lu, Xu, Wang, Zhao, Peng, Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of potential ESCC immune subtypes. (A) Consensus clustering the cumulative distribution function curve for k = 2 to k = 9. (B) Relative change in area under the cumulative distribution function curve. (C–F) Clustering heatmap for k = 2 to k = 5. (G) PCA plot showing the distribution of IS1 and IS2. (H) Kaplan–Meier curve showing the OS of IS1 and IS2 in the TCGA cohort. (I) Heatmaps showing the relationship between potential ESCC antigens and clinical characteristics in different immune subtypes. (J–M) Distribution ratio of IS1 and IS2 across age, gender, stage and survival status in ESCC patients.