Table 2.
Radiographic and laboratory findings of 116 patients with Chlamydia psittaci pneumonia
| Variables | All patients (N = 116) | Non-severe group (N = 63) | Severe group (N = 53) | p values (< 0.050) | Survive group (N = 43) | Non-survive group (N = 10) | p values (< 0.050) | Normal range |
|---|---|---|---|---|---|---|---|---|
| Computed tomography images | N = 96 | N = 52 | N = 44 | N = 34 | N = 10 | |||
| Left pulmonary involvement | 20 (20.8%) | 11 (21.2%) | 9 (20.5%) | 0.933 | 9 (26.5%) | 0 (0%) | 0.068 | / |
| Right pulmonary involvement | 27 (28.1%) | 22 (42.3%) | 5 (11.4%) | 0.001 | 2 (5.9%) | 3 (30.0%) | 0.035 | / |
| Bilateral pulmonary involvement | 51 (53.1%) | 21 (40.4%) | 30 (68.2%) | 0.007 | 23 (67.6%) | 7 (70.0%) | 0.888 | / |
| Consolidation | 95 (99.0%) | 51 (98.1%) | 44 (100.0%) | 0.355 | 34 (100.0%) | 10 (100.0%) | 1 | / |
| Interstitial change | 5 (5.2%) | 3 (5.8%) | 2 (4.5%) | 0.788 | 2 (5.9%) | 0 (0%) | 0.432 | / |
| Pleural effusion | 42 (43.8%) | 20 (38.5%) | 22 (50.0%) | 0.256 | 17 (50.0%) | 5 (50.0%) | 1 | / |
| Metagenomic next-generation sequencing | ||||||||
| Airway sample sent for detection | 106 (91.4%) | 58 (92.1%) | 48 (90.6%) | 0.775 | 39 (90.7%) | 9 (90.0%) | 0.946 | / |
| Blood sample sent for detection | 17 (14.7%) | 8 (12.7%) | 9 (17.0%) | 0.516 | 6 (14.0%) | 3 (30.0%) | 0.223 | / |
| Airway and blood samples sent for detection | 7 (6.0%) | 3 (4.8%) | 4 (7.5%) | 0.530 | 2 (4.7%) | 2 (20.0%) | 0.098 | / |
| Airway/blood DNA sequence number of C. psittaci | 100.0 (23.8–372.8) | 56.0 (9.5–202.5) | 113.0 (57.0–531.0) | 0.015 | 100.0 (31.5–433.0) | 593.9 (641.4) | 0.165 | 0.0 |
| Airway DNA sequence number of C. psittaci | 107.0 (30.2–285.2) | 107.0 (23.5–191.5) | 107.0 (76.0–412.0) | 0.066 | 107.0 (34.5–348.0) | 55.0 (107.0–859.2 | 0.303 | 0.0 |
| Combine detection of bacteria | 19.0 (16.4%) | 11.0 (17.5%) | 8.0 (15.1%) | 0.732 | 7 (16.3%) | 1 (10.0%) | 0.617 | 0.0% |
| Combine detection of fungal infection | 21.0 (18.1%) | 12.0 (19.0%) | 9.0 (17.0%) | 0.773 | 7 (16.3%) | 2 (20.0%) | 0.778 | 0.0% |
| Combine detection of virus | 12.0 (10.3%) | 6.0 (9.5%) | 6.0 (11.3%) | 0.752 | 5 (11.6%) | 1 (10.0%) | 0.884 | 0.0% |
| Blood routine | ||||||||
| White blood cell count (× 109/L) | 7.8 (5.6–10.4) | 7.6 (5.8–9.5) | 9.3 (4.8) | 0.228 | 9.1 (4.9) | 10.1 (4.5) | 0.552 | 4.00–10.00 |
| Neutrophil percentage (%) | 87.1 (82.0–90.8) | 86.8 (80.7–89.2) | 89.0 (85.1–93.7) | 0.003 | 88.6 (84.5–92.5) | 90.7 (5.0) | 0.172 | 50.00–70.00 |
| Lymphocyte percentage (%) | 7.3 (5.1–10.0) | 7.4 (7.3–11.0) | 6.5 (3.5–7.4) | < 0.001 | 6.8 (3.9) | 4.3 (2.4) | 0.043 | 20.00–40.00 |
| Neutrophil-to-lymphocyte ratio | 12.1 (8.2–17.1) | 11.9 (7.6–12.1) | 13.7 (12.1–26.4) | < 0.001 | 12.6 (10.8–21.3) | 27.4 (14.8) | 0.046 | 1.25–3.5 |
| Hemoglobin (g/L) | 115.0 (106.8–121.0) | 115.0 (110.5–127.5) | 109.4 (17.3) | 0.041 | 108.7 (18.0) | 112.5 (14.4) | 0.537 | 110–160 |
| Platelet count (× 109/L) | 190.0 (166.0–207.5) | 190.0 (168.0–217.5) | 182.9 (66.6) | 0.257 | 190.4 (66.7) | 150.7 (58.6) | 0.089 | 100–300 |
| Biochemistry tests | ||||||||
| Albumin (g/L) | 28.2 (4.4) | 29.3 (4.5) | 26.9 (3.8) | 0.003 | 26.7 (3.8) | 27.7 (3.8) | 0.483 | 35.0–55.0 |
| Globulin (g/L) | 26.9 (26.4–27.4) | 27.6 (3.8) | 26.0 (3.8) | 0.018 | 26.2 (3.4) | 25.4 (5.5) | 0.676 | 20.2–29.5 |
| Albumin-to-globulin ratio | 1.1 (1.1–1.1) | 1.1 (1.1–1.1) | 1.1 (1.1–1.1) | 0.749 | 1.1 (1.1–1.1) | 1.1 (0.3) | 0.617 | 1.5–2.5 |
| Alanine aminotransferase (U/L) | 63.5 (47.8–99.3) | 63.5 (44.0–97.2) | 63.5 (48.2–98.9) | 0.644 | 63.5 (51.0–99.7) | 68.1 (28.3) | 0.600 | 0.0–42.0 |
| Aspartate aminotransferase (U/L) | 100.1 (57.9–146.1) | 100.1 (50.2–138.9) | 100.1 (77.6–156.0) | 0.109 | 100.1 (63.4–153.6) | 143.0 (78.8) | 0.500 | 0.0–37.0 |
| Total bilirubin (μmol/L) | 12.7 (12.7–12.8) | 12.7 (12.1–12.7) | 12.7 (12.7–14.8) | 0.422 | 12.7 (12.7–15.8) | 12.2 (9.7–12.7) | 0.052 | 3.4–17.1 |
| Direct bilirubin (μmol/L) | 6.3 (6.2–6.8) | 6.3 (6.0–6.3) | 6.3 (6.3–9.5) | 0.228 | 6.3 (6.3–10.8) | 6.2 (5.0–6.3) | 0.077 | 0.0–6.0 |
| Blood urea nitrogen (mmol/L) | 5.8 (5.7–6.3) | 5.3 (1.7) | 5.8 (5.8–9.4) | < 0.001 | 5.8 (5.8–8.4) | 10.5 (7.0) | 0.674 | 2.9–7.14 |
| Creatinine (μmol/L) | 74.8 (69.8–80.0) | 73.4 (17.0) | 74.8 (74.8–95.2) | 0.035 | 74.8 (74.8–88.0) | 74.8 (62.8–122.8) | 0.575 | 44.0–133.0 |
| Creatine kinase (U/L) | 237.0 (227.4–274.0) | 237.0 (160.5–237.0) | 237.0 (237.0–326.0) | 0.296 | 237.0 (237.0–295.5) | 296.7 (122.6) | 0.634 | 10.0–190.0 |
| Lactate dehydrogenase (U/L) | 394.7 (393.4–396.0) | 394.7 (307.1–394.7) | 394.7 (394.7–482.6) | 0.006 | 394.7 (394.7–464.8) | 508.8 (210.8) | 0.487 | 80.0–245.0 |
| Infection biomarkers | ||||||||
| Erythrocyte sedimentation rate (mm/h) | 86.0 (81.8–89.0) | 86.0 (86.0–90.5) | 86.0 (75.0–87.0) | 0.256 | 86.0 (77.0–88.5) | 75.1 (20.0) | 0.277 | 0.0–15.0 |
| High-sensitivity C-reactive protein (mg/L) | 162.0 (107.2–240.1) | 149.0 (79.3–198.2) | 197.6 (95.3) | 0.011 | 192.0 (95.9) | 221.7 (93.9) | 0.380 | 0.0–8.0 |
| Procalcitonin (mg/L) | 1.1 (0.3–4.9) | 0.5 (0.2–1.1) | 3.9 (1.1–9.8) | < 0.001 | 3.4 (1.1–10.0) | 7.2 (5.6) | 0.488 | 0.0–0.05 |
| D-dimer (mg/L) | 1.8 (1.4–3.2) | 1.8 (1.0–1.8) | 1.8 (1.8–4.8) | < 0.001 | 1.8 (1.8–4.7) | 2.5 (1.8–8.2) | 0.773 | 0.0–0.05 |
| Blood gas analysis | ||||||||
| Hydrogen ion concentration | 7.5 (7.5–7.5) | 7.5 (7.5–7.5) | 7.5 (7.5–7.5) | 0.234 | 7.5 (7.5–7.5) | 7.4 (0.1) | 0.049 | 7.35–7.45 |
| Partial pressure of carbon dioxide (mmHg) | 29.1 (29.1–29.1) | 29.1 (29.1–29.1) | 29.1 (29.1–32.0) | 0.062 | 29.1 (29.1–30.6) | 35.0 (9.8) | 0.095 | 35.0–45.0 |
| Oxygenation index (mmHg) | 241.0 (241.0–241.0) | 253.0 (68.5) | 241.0 (166.7–241.0) | 0.009 | 241.0 (198.6–241.0) | 194.8 (129.5) | 0.186 | 400.0–500.0 |
Values are numbers (percentages) or median (IQR) unless stated otherwise. Percentages do not total to 100% owing to missing data