Table 1.
Clinical core characteristics.
| ID | Sex | Age at death [years] | MRI-Death [d] | Death -MRI [d] | N tissue blocks | Main clinical diagnosis | Cause of death | Main neuropathological findings |
|---|---|---|---|---|---|---|---|---|
| #1-19 | Female | 78 | 25 | 402 | SH: 0DH: 5 | Brain tumor; Diabetes mellitus typ II; Atherosclerosis, Gastrointestinal haemorrhages | Fever, peripheral septic conditions, hypotension | Glioblastoma, IDH1 wild type |
| #22-19 | Female | 39 | 241 | 329 | SH: 6DH: 0 | Decompensated hepatic cirrhosis; Hypertrophic obstructive cardiomyopathy; Chronic kidney disease | Cardiopulmonary resuscitation | Diffuse white matter injury |
| #42-19 | Female | 35 | 1 | 280 | SH: 8DH: 4 | Morbus Hodgkin; HIV (CDC: 3); HCV | Morbus Hodgkin with brainstem involvement | Meningeosis leucaemica, leukoencephalopathy in the right temporal lobe, prominent brain edema |
| #66-18 | Female | 57 | 132 | 618 | SH: 0DH: 3 | Tuberculosis; Constrictive pericarditis; Diabetes mellitus typ II | Cerebral tuberculosis | St.p. brain biopsy of right-postcentral granulomatous-necrotizing inflammation with post-vasculitic vessel abnormalities |
| #95-19 | Male | 74 | 135 | 181 | SH: 4DH: 6 | Diffuse large B-cell lymphoma; Sarcopenia; Acute kidney injury | Not further specified, death occurred at a palliative care unit | Meningeosis lymphomatosa, cerebral amyloid angiopathy (Thal type 2) without hemorrhagic complications |
| #100-19 | Male | 75 | 11 | 174 | SH: 2DH: 7 | Amyloid angiopathy; Diffuse large B-cell lymphoma; Atrial fibrillation; Arterial hypertension | Right-heart failure | Moderate meningeosis lymphomatosa |
| #104-19 | Male | 57 | 8 | 192 | SH: 0DH: 8 | Breast Cancer | Meningeal carcinomatosis, multiple tumor-thromboses | Breast cancer with widespread dural metastases, partial sinus thrombosis, multiple leptomeningeal vessel obliterations, multiple acute cortical microinfarcts |
| #112-18 | Female | 49 | 15 | 513 | SH: 2DH: 2 | Gastric cancer, Sarcopenia | Brain metastasis | Cortical infarcts left occipital, in watershed distribution, marked brain edema |
| #120-19 | Female | 77 | 138 | 123 | SH: 7DH: 2 | Cardiomyopathy not further specified; Chronic kidney disease; Paroxysmal atrial fibrillation; Dementia not further specified; Hypothyreosis | Hemorrhage during thrombectomy | Vessel wall amyloidosis in choroid plexus and dural vessels, partially recanalized thrombosis of the left ACM, associated subacute cortical infarct in the left temporoparietal region, moderate AD pathology, fibrotic vessel walls of small intracerebral arteries, chronic subdural hematoma |
| #125-19 | Female | 67 | 17 | 104 | SH: 3DH: 5 | Recurrent craniopharyngioma | Cardiorespiratory failure | St.p. adamantinomatous craniopharyngeoma resection, severe ischaemic cerebellar Purkinje cell loss, diffuse arteriolosclerosis |
| #140-19 | Female | 52 | 36 | 103 | SH: 0DH: 4 | Adenocarcinoma of the lacrimal gland | Multi organ failure | St.p. opticus glioma resection, St.p. resection of carcinoma of lacrimal gland, marked diffuse brain edema, cystic tissue defects in both basal rostral basal ganglia (diameter 2.5 cm), Dura with tumour infiltration in the region of the tractus opticus |
| #151-18 | Female | 77 | 19 | 409 | SH: 0DH: 3 | Diffuse large B-cell lymphoma; Venous thromboembolism; Acute kidney injury | Multi organ failure under peripheral septic conditions | Moderate brain edema, mild unspecific terminal brainstem encephalitis, iron deposition and axonal degeneration in the basal ganglia reminiscent of neurodegeneration with brain iron accumulation |
| Female: male = 9:3 | median: 62 (25% to 75%: 50 to 77) | median: 22 (25% to 75%: 12 to 134) | median: 236 (25% to 75%: 136 to 407) | Total: SH: 32DH: 49 | ||||
Note: Sex, age, the time interval from last in vivo MRI to death, the time interval from death to the post-mortem MRI, and clinical core diagnosis/cause of death are summarized for each study subject.
SH: single-hemispheric; DH: double-hemispheric.