Table 2.

Overview of the 19 significantly correlating biomarkers with white matter hyperintensity volume.^a

Biomarker (abbreviation)	Pearson's r	Bonferroni correctedp-value
Growth differentiation factor 15 (GDF15)	0.270	<0.001
Cystatin B (CSTB)	0.242	<0.001
Secreted phosphoprotein 1 (SPP1)	0.233	<0.001
TNF receptor superfamily member 14 (TNFRSF14)	0.219	<0.001
TNF receptor superfamily member 11 b (TNFRSF11B)	0.215	<0.001
TIMP metallopeptidase inhibitor 4 (TIMP4)	0.203	<0.001
Trefoil factor 3 (TFF3)	0.202	<0.001
Plasminogen activator, urokinase receptor (PLAUR)	0.198	<0.001
Spondin 1 (SPON1)	0.180	0.005
F11 receptor (F11R)	0.180	0.006
TNF receptor superfamily member 1 A (TNFRSF1A)	0.179	0.006
Azurocidin 1 (AZU1)	0.175	0.008
Lymphotoxin beta receptor (LTBR)	0.173	0.010
Natriuretic peptide B (NPPB)	0.172	0.010
Retinoic acid receptor responder 2 (RARRES2)	0.172	0.012
Glycoprotein VI platelet (GP6)	0.170	0.016
Heparan sulfate proteoglycan 2 (HSPG2)	0.169	0.014
Platelet derived growth factor subunit A (PDGFA)	0.160	0.030
Von Willebrand factor (VWF)	0.156	0.045

Data are expressed as correlation coefficients (Pearson’s r) with corresponding Bonferroni corrected p-values.

^aWe entered the natural logarithm of white matter hyperintensity volume (expressed as % of total brain volume) in the Pearson correlation analyses.