Table 3.

Statistically enriched biological pathways reflected by the identified 16-component biomarker cluster.

Pathway	No. of biomarkers found/Total no. of biomarkers inpathway (Reactome)	p-value	FDR	Biomarkers
Coagulation pathways
Platelet Adhesion to exposed collagen	2/25	<0.001	<0.001	GP6;VWF
Platelet activation, signaling and aggregation	4/264	<0.001	0.012	GP6;VWF;RARRES2;PDGFA
Platelet degranulation	3/128	0.001	0.012	VWF;RARRES2;PDGFA
Response to elevated plateletcytosolic Ca2+	3/133	0.001	0.012	VWF;RARRES2;PDGFA
Defective F8 binding to vonWillebrand factor	1/2	0.003	0.031	VWF
Hemostasis	5/726	0.004	0.035	PLAUR;GP6;VWF;RARRES2;PDGFA
Defective F8 cleavage by thrombin	1/3	0.004	0.038	VWF
Inflammation pathways
TNFs bind their physiological receptors	3/30	<0.001	<0.001	TNFRSF1A;TNFRSF14;TNFRSF11B
TNFR2 non-canonical NF-kB pathway	4/102	<0.001	<0.001	TNFRSF1A;TNFRSF14;LTBR;TNFRSF11B
Angiogenesis pathways
Signaling by PDGF	2/60	<0.001	<0.001	SPP1;PDGFA
Downstream signal transduction	1/31	0.001	0.012	PDGFA
ECM organization pathways
Integrin cell surface interactions	3/85	<0.001	0.007	VWF;SPP1;HSPG2
ECM organization	4/301	0.001	0.012	PDGFA;VWF;SPP1;HSPG2
Non-integrin membrane-ECM interactions	2/59	0.003	0.035	PDGFA;HSPG2

FDR: false discovery rate; TNF: tumor necrosis factor; TNFR2: tumor necrosis factor receptor 2; No.: number; NF-kB: nuclear factor-kB; PDGF: Platelet-derived Growth Factor; ECM: extracellular matrix.

Data are presented as the number of biomarkers found per pathway (expressed as a fraction of the total number of biomarkers known to be involved per pathway based on the Reactome database) with corresponding p-values and FDRs. A statistically significant p-value implies that the number of biomarkers identified within a pathway is higher than would be expected by chance.