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. 2022 Jun 6;13:823121. doi: 10.3389/fimmu.2022.823121

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Copyright © 2022 Haist, Ries, Gunzer, Bednarczyk, Siegel, Kuske, Grabbe, Radsak, Bros and Teschner

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Impaired oxidative and non-oxidative effector functions of CD18-deficient PMN. We could observe that the formation of NET after 3h of incubation (A) and ROS-generation (B) were significantly lower in PMN derived from CD18^Ly6G cKO mice, particularly after stimulation with A. fumigatus conidia. Data represent the mean ± SEM of 3 samples analyzed/group. Statistically significant differences between groups are indicated (*p<0.05)